Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1847986..1848488 Replicon chromosome
Accession NZ_CP062895
Organism Escherichia coli strain Res13-Lact-ER02-39

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IMP38_RS08735 Protein ID WP_000767829.1
Coordinates 1848234..1848488 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IMP38_RS08730 Protein ID WP_001259255.1
Coordinates 1847986..1848237 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP38_RS08705 1843164..1844231 - 1068 WP_029397756.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IMP38_RS08710 1844231..1845301 - 1071 WP_000108937.1 histidinol-phosphate transaminase -
IMP38_RS08715 1845298..1846602 - 1305 WP_021545648.1 histidinol dehydrogenase -
IMP38_RS08720 1846608..1847507 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
IMP38_RS08725 1847653..1847703 - 51 WP_001364200.1 his operon leader peptide -
IMP38_RS08730 1847986..1848237 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IMP38_RS08735 1848234..1848488 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IMP38_RS08740 1848571..1849395 + 825 WP_000754758.1 SDR family oxidoreductase -
IMP38_RS08745 1849441..1850370 + 930 WP_000803351.1 LysR family transcriptional regulator -
IMP38_RS08750 1850585..1850647 + 63 WP_010723108.1 membrane protein YoeI -
IMP38_RS08755 1850637..1851995 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IMP38_RS08760 1852174..1853232 + 1059 WP_000492346.1 transport protein YeeE -
IMP38_RS08765 1853246..1853473 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T177191 WP_000767829.1 NZ_CP062895:1848234-1848488 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T177191 NZ_CP083273:c4493398-4493291 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT177191 WP_001259255.1 NZ_CP062895:1847986-1848237 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT177191 NZ_CP083273:4493445-4493511 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References