177151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 586817..587616 Replicon chromosome
Accession NZ_CP062889
Organism Escherichia coli O100:H21 strain Res13-Lact-ER07-18

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag IMP41_RS02830 Protein ID WP_000347266.1
Coordinates 586817..587281 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IMP41_RS02835 Protein ID WP_001307405.1
Coordinates 587281..587616 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP41_RS02800 581818..582252 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IMP41_RS02805 582270..583148 - 879 WP_001315856.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IMP41_RS02810 583138..583917 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMP41_RS02815 583928..584401 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMP41_RS02820 584424..585704 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMP41_RS02825 585953..586762 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IMP41_RS02830 586817..587281 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMP41_RS02835 587281..587616 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMP41_RS02840 587765..589336 - 1572 WP_001273741.1 galactarate dehydratase -
IMP41_RS02845 589711..591045 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IMP41_RS02850 591061..591831 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T177151 WP_000347266.1 NZ_CP062889:c587281-586817 [Escherichia coli O100:H21]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T177151 NZ_CP083259:c2058980-2058729 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT177151 WP_001307405.1 NZ_CP062889:c587616-587281 [Escherichia coli O100:H21]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT177151 NZ_CP083259:c2058739-2058566 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References