Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 107463..107965 Replicon chromosome
Accession NZ_CP062876
Organism Escherichia coli O157:H16 strain Res13-Lact-PEA12-26

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IMP69_RS00525 Protein ID WP_000767829.1
Coordinates 107711..107965 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IMP69_RS00520 Protein ID WP_001259252.1
Coordinates 107463..107714 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP69_RS00495 102641..103708 - 1068 WP_195686591.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IMP69_RS00500 103708..104778 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
IMP69_RS00505 104775..106079 - 1305 WP_001317939.1 histidinol dehydrogenase -
IMP69_RS00510 106085..106984 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
IMP69_RS00515 107130..107180 - 51 WP_001364200.1 his operon leader peptide -
IMP69_RS00520 107463..107714 + 252 WP_001259252.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IMP69_RS00525 107711..107965 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IMP69_RS00530 108048..108872 + 825 WP_000754763.1 SDR family oxidoreductase -
IMP69_RS00535 108918..109847 + 930 Protein_106 LysR family transcriptional regulator -
IMP69_RS00540 110062..110124 + 63 WP_010723108.1 membrane protein YoeI -
IMP69_RS00545 110114..111472 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IMP69_RS00550 111651..112709 + 1059 WP_032294221.1 transport protein YeeE -
IMP69_RS00555 112723..112950 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T177072 WP_000767829.1 NZ_CP062876:107711-107965 [Escherichia coli O157:H16]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T177072 NZ_CP083070:358085-358432 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9279.57 Da        Isoelectric Point: 4.7954

>AT177072 WP_001259252.1 NZ_CP062876:107463-107714 [Escherichia coli O157:H16]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARKLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT177072 NZ_CP083070:358432-358731 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References