Detailed information of TA system TA177019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3886941..3887199
• Replicon: chromosome
• Accession: NZ_CP062868
• Organism: Escherichia coli strain Res13-Lact-PEB01-20

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: IMP84_RS18595
• Protein ID: WP_000935262.1
• Coordinates: 3886990..3887199 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3886941..3886998 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMP84_RS18575	3881989..3883320	+	1332	Protein_3631	fimbria/pilus outer membrane usher protein	-
IMP84_RS18580	3883333..3884291	+	959	Protein_3632	fimbrial family protein	-
IMP84_RS18585	3884330..3885229	-	900	WP_001300855.1	transcriptional activator NhaR	-
IMP84_RS18590	3885295..3886461	-	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
-	3886941..3886998	-	58	-	-	Antitoxin
IMP84_RS18595	3886990..3887199	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
IMP84_RS18600	3887303..3888433	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
IMP84_RS18605	3888522..3890438	-	1917	WP_000516135.1	molecular chaperone DnaK	-
IMP84_RS18610	3890815..3891219	+	405	WP_047672534.1	DUF2541 family protein	-
IMP84_RS18615	3891245..3891958	+	714	WP_001102379.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T177019 WP_000935262.1 NZ_CP062868:3886990-3887199 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T177019 NZ_CP083048:175341-175625 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT177019 NZ_CP062868:c3886998-3886941 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin