Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 714004..714697 Replicon chromosome
Accession NZ_CP062851
Organism Escherichia coli O9:H10 strain Res13-Lact-PEB21-38-A

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IMQ03_RS03475 Protein ID WP_000415584.1
Coordinates 714004..714300 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IMQ03_RS03480 Protein ID WP_000650107.1
Coordinates 714302..714697 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ03_RS03440 709092..709406 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IMQ03_RS03445 709437..710018 - 582 WP_001569186.1 NADPH:quinone oxidoreductase MdaB -
IMQ03_RS03450 710337..710669 + 333 WP_000917684.1 DUF2645 family protein -
IMQ03_RS03455 710715..712064 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IMQ03_RS03460 712061..712720 - 660 WP_001221493.1 two-component system response regulator QseB -
IMQ03_RS03465 712872..713264 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IMQ03_RS03470 713317..713799 + 483 WP_000183505.1 transcriptional regulator -
IMQ03_RS03475 714004..714300 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IMQ03_RS03480 714302..714697 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IMQ03_RS03485 714830..716437 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IMQ03_RS03490 716575..718833 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T176847 WP_000415584.1 NZ_CP062851:714004-714300 [Escherichia coli O9:H10]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T176847 NZ_CP082976:252941-253225 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAATATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT176847 WP_000650107.1 NZ_CP062851:714302-714697 [Escherichia coli O9:H10]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT176847 NZ_CP082976:252703-252951 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References