Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725477..726170 Replicon chromosome
Accession NZ_CP062832
Organism Escherichia coli strain Res13-Lact-PER04-33

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IMQ22_RS03510 Protein ID WP_000415584.1
Coordinates 725477..725773 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IMQ22_RS03515 Protein ID WP_000650107.1
Coordinates 725775..726170 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ22_RS03475 720565..720879 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IMQ22_RS03480 720910..721491 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IMQ22_RS03485 721810..722142 + 333 WP_000917684.1 DUF2645 family protein -
IMQ22_RS03490 722188..723537 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IMQ22_RS03495 723534..724193 - 660 WP_001221493.1 two-component system response regulator QseB -
IMQ22_RS03500 724345..724737 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IMQ22_RS03505 724790..725272 + 483 WP_032200589.1 GyrI-like domain-containing protein -
IMQ22_RS03510 725477..725773 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IMQ22_RS03515 725775..726170 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IMQ22_RS03520 726303..727910 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IMQ22_RS03525 728048..730306 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T176776 WP_000415584.1 NZ_CP062832:725477-725773 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T176776 NZ_CP082930:19666-19941 [Salmonella enterica subsp. enterica serovar London]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCAGTCATTCTGTTAACTCATCCACGTATAGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT176776 WP_000650107.1 NZ_CP062832:725775-726170 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT176776 NZ_CP082930:19382-19666 [Salmonella enterica subsp. enterica serovar London]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References