Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725472..726165 Replicon chromosome
Accession NZ_CP062826
Organism Escherichia coli strain Res13-Lact-PER12-33-A

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IMQ30_RS03510 Protein ID WP_000415584.1
Coordinates 725472..725768 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IMQ30_RS03515 Protein ID WP_000650107.1
Coordinates 725770..726165 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ30_RS03475 720560..720874 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IMQ30_RS03480 720905..721486 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IMQ30_RS03485 721805..722137 + 333 WP_000917684.1 DUF2645 family protein -
IMQ30_RS03490 722183..723532 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IMQ30_RS03495 723529..724188 - 660 WP_001221493.1 two-component system response regulator QseB -
IMQ30_RS03500 724340..724732 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IMQ30_RS03505 724785..725267 + 483 WP_032200589.1 GyrI-like domain-containing protein -
IMQ30_RS03510 725472..725768 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IMQ30_RS03515 725770..726165 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IMQ30_RS03520 726298..727905 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IMQ30_RS03525 728043..730301 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T176740 WP_000415584.1 NZ_CP062826:725472-725768 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T176740 NZ_CP082922:3812301-3812696 [Nocardioides rotundus]
GTGAGTGCGCCGTACCTGCTCGACGCGAACGCTCTCATCGCACTCGTCGTCGCGGAGCACGAGCACCACGGCCGGGTGGC
CCAGTGGGCGGGAGACGTGGAGCGTCTCGCGCTGTGCCCCATCGTCGAGGGCGCACTGGTCCGCTTCCTACTCCGGCTCG
GGGCGAGCGGTGCGACGGCCCAGGCCCTGCTCACGGCTCTGCACGCGTCGGGCCGTTGCGAGTTCTGGGAGGACTCGATC
TCCTACCGCTCGGTCGACCTCGACCACGTGCTCGGCCACCGGCAGGTGACCGACGCCTACCTGGCCGACCTCGCCGAGAG
TCGGGGAGCACGGCTCGCCACCCTCGACCGGGCGCTCGCCTCCGCCCGCCCGCAGGCCACGTACCTGATCGCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT176740 WP_000650107.1 NZ_CP062826:725770-726165 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT176740 NZ_CP082922:3812074-3812304 [Nocardioides rotundus]
ATGAGGACGACCATCGACCTGCCCCCGGCGGTGCACCGACGTGCCCGCGAGATCGCTCGGGCCCGGCAGCAGTCGCTGTC
GTCCGTGGTCGCCGAGCTGGCCACGCGAGGCCTGAACGCCCTCGGCGATCCGGTGGAGGTGGGGACCGATCCGGTCAGCG
GACTCCCGGCGGTCACGCTGGGTCAGCGGGTGACCAGCGACGACGTCGCGAACGCGCTGGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References