Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3681232..3682031 Replicon chromosome
Accession NZ_CP062824
Organism Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag IMQ31_RS17450 Protein ID WP_000347269.1
Coordinates 3681232..3681696 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IMQ31_RS17455 Protein ID WP_001307405.1
Coordinates 3681696..3682031 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ31_RS17420 3676233..3676667 - 435 WP_000948837.1 PTS sugar transporter subunit IIA -
IMQ31_RS17425 3676685..3677563 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IMQ31_RS17430 3677553..3678332 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMQ31_RS17435 3678343..3678816 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMQ31_RS17440 3678839..3680119 - 1281 WP_085459069.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMQ31_RS17445 3680368..3681177 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
IMQ31_RS17450 3681232..3681696 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMQ31_RS17455 3681696..3682031 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMQ31_RS17460 3682180..3683751 - 1572 WP_001273738.1 galactarate dehydratase -
IMQ31_RS17465 3684126..3685460 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
IMQ31_RS17470 3685476..3686246 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T176730 WP_000347269.1 NZ_CP062824:c3681696-3681232 [Escherichia coli O167:H26]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

>T176730 NZ_CP082922:c299637-299356 [Nocardioides rotundus]
GTGACCGAGCCCGGGACCGAATGGCGAGTCGAGTTCTCCTCGGCGGCGGTCCGGTCGCTGGACCGGCTTCCGGAGAAGGT
GGCTGCGGCGGTGGTCGAGTTCACCACCGGCACGCTCCCGACCAACCCCCATCGGCTCTCCCAGCAACTCCAGGCCGAGC
TCGCTGGCTGGCGGGTCGCCCGTCGGGGCAGCTACCGAGTCACCTTCCAGATCCTCGACCAGGATCGAGTCCTGCTCGTC
GGGCGGATCGACCACCGAGCCGACATCTACCGACGGCGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT176730 WP_001307405.1 NZ_CP062824:c3682031-3681696 [Escherichia coli O167:H26]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT176730 NZ_CP082922:c299909-299634 [Nocardioides rotundus]
ATGAAGACCGTCGCCCTCAGTGAGGCCAAGGACAAGCTCTCCGCGCTCGTCGACGAGGCGGAGAGCACCCACGAGATCAT
CACCATCACTCGGCATGGTCACAACGCCGCGGTCTTGATCGCGGCCGACGAGCTGGAGTCGATGCGCGAGACGATCAGGT
TGCTCTCGACGCCCGGAACGGTTGAAGAGCTCGACCGTGCGCGCGAGGAGTACGCCGCCGGCGGGACCACTGGCGGCGAC
GACCTCCGGAGCCGCTTCGGCCTCACCAGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References