Detailed information of TA system TA176670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1847851..1848353
• Replicon: chromosome
• Accession: NZ_CP062815
• Organism: Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: U9YDH0
• Locus tag: IMQ58_RS08735
• Protein ID: WP_000767829.1
• Coordinates: 1848099..1848353 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: S1Q063
• Locus tag: IMQ58_RS08730
• Protein ID: WP_001259255.1
• Coordinates: 1847851..1848102 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ58_RS08705	1843029..1844096	-	1068	WP_029397756.1	bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB	-
IMQ58_RS08710	1844096..1845166	-	1071	WP_000108937.1	histidinol-phosphate transaminase	-
IMQ58_RS08715	1845163..1846467	-	1305	WP_021545648.1	histidinol dehydrogenase	-
IMQ58_RS08720	1846473..1847372	-	900	WP_000131782.1	ATP phosphoribosyltransferase	-
IMQ58_RS08725	1847518..1847568	-	51	WP_001364200.1	his operon leader peptide	-
IMQ58_RS08730	1847851..1848102	+	252	WP_001259255.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
IMQ58_RS08735	1848099..1848353	+	255	WP_000767829.1	type II toxin-antitoxin system mRNA interferase toxin YoeB	Toxin
IMQ58_RS08740	1848436..1849260	+	825	WP_000754758.1	SDR family oxidoreductase	-
IMQ58_RS08745	1849306..1850235	+	930	WP_000803351.1	LysR family transcriptional regulator	-
IMQ58_RS08750	1850450..1850512	+	63	WP_010723108.1	membrane protein YoeI	-
IMQ58_RS08755	1850502..1851860	+	1359	WP_000019197.1	putrescine/proton symporter PlaP	-
IMQ58_RS08760	1852039..1853097	+	1059	WP_000492346.1	transport protein YeeE	-
IMQ58_RS08765	1853111..1853338	+	228	WP_000985273.1	sulfurtransferase TusA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10183.58 Da
• Isoelectric Point: 8.0353

>T176670 WP_000767829.1 NZ_CP062815:1848099-1848353 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Nucleotide

• Length: 255 bp

>T176670 NZ_CP082895:c13077-12718 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9307.58 Da
• Isoelectric Point: 4.7954

>AT176670 WP_001259255.1 NZ_CP062815:1847851-1848102 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Nucleotide

• Length: 252 bp

>AT176670 NZ_CP082895:c12718-12419 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• PDB: 6NY6
• PDB: 2A6S
• PDB: 6OXA
• PDB: 2A6R
• PDB: 4V8X
• PDB: 6OTR
• PDB: 6OXI
• PDB: 2A6Q

Antitoxin

• AlphaFold DB: A0A7U9LNR0