Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3899307..3899848 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag IMQ59_RS18640 Protein ID WP_000615980.1
Coordinates 3899570..3899848 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag IMQ59_RS18635 Protein ID WP_000729709.1
Coordinates 3899307..3899567 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS18615 3894990..3895775 - 786 WP_000207555.1 putative lateral flagellar export/assembly protein LafU -
IMQ59_RS18620 3895747..3897459 + 1713 Protein_3649 flagellar biosynthesis protein FlhA -
IMQ59_RS18625 3897675..3898172 - 498 WP_001624615.1 REP-associated tyrosine transposase RayT -
IMQ59_RS18630 3898348..3899097 - 750 WP_024191992.1 C40 family peptidase -
IMQ59_RS18635 3899307..3899567 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IMQ59_RS18640 3899570..3899848 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IMQ59_RS18645 3900004..3900744 + 741 WP_195691383.1 murein L,D-transpeptidase -
IMQ59_RS18650 3900715..3901482 - 768 WP_000333379.1 class II glutamine amidotransferase -
IMQ59_RS18655 3901688..3902266 - 579 WP_000284053.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T176652 WP_000615980.1 NZ_CP062811:3899570-3899848 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T176652 NZ_CP082860:c4270191-4269952 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT176652 WP_000729709.1 NZ_CP062811:3899307-3899567 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT176652 NZ_CP082860:c4270423-4270181 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGTTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References