Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 646685..647484 Replicon chromosome
Accession NZ_CP062811
Organism Escherichia coli strain Res13-Sevr-PER07-33

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag IMQ59_RS03070 Protein ID WP_000347273.1
Coordinates 646685..647149 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A5E8JFT0
Locus tag IMQ59_RS03075 Protein ID WP_001626029.1
Coordinates 647149..647484 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ59_RS03040 641685..642119 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IMQ59_RS03045 642137..643016 - 880 Protein_597 PTS mannose/fructose/sorbose transporter family subunit IID -
IMQ59_RS03050 643006..643785 - 780 WP_000406200.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IMQ59_RS03055 643796..644269 - 474 WP_001626031.1 PTS N-acetylgalactosamine transporter subunit IIB -
IMQ59_RS03060 644292..645572 - 1281 WP_000681939.1 tagatose-bisphosphate aldolase subunit KbaZ -
IMQ59_RS03065 645821..646630 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IMQ59_RS03070 646685..647149 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IMQ59_RS03075 647149..647484 - 336 WP_001626029.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IMQ59_RS03080 647633..649204 - 1572 WP_021574785.1 galactarate dehydratase -
IMQ59_RS03085 649579..650913 + 1335 WP_000599633.1 galactarate/glucarate/glycerate transporter GarP -
IMQ59_RS03090 650929..651699 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T176634 WP_000347273.1 NZ_CP062811:c647149-646685 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T176634 NZ_CP082855:c116481-116200 [Legionella anisa]
ATGCTTGAATTAGAGTTGGCGACACAGTTTAAGCGTGATTTGAAAAAGATTACGAAGCAAGGGAAAAGAAGGACGCTCTT
AGACTCTATTGTAGAGCAATTGCAAAAGGAAGAACCCCTGGATCCAAAGCATAAGGATCACAGTCTTTCCGTAAATTGGG
ATGGTTATCGTGAATGTCACATTACCCCCGATTGGTTATTAATTTATAAGACCATTAAAGATGATCGCATACAATTGCTG
CGATTATCACGAACAGGATCACATAGTGATTTGTTTGGGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12344.91 Da        Isoelectric Point: 4.8616

>AT176634 WP_001626029.1 NZ_CP062811:c647484-647149 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNVDDEIGDDE

Download         Length: 336 bp

>AT176634 NZ_CP082855:c116734-116474 [Legionella anisa]
ATGAATAAGGCGGCAACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCAGAAGCGATTTTGCATAAGGTAGG
CTTATCTACAGCCGAGGCGATTCGACTGTTCTATAGCCAGGTCTGTCTCCAAAATGGCCTGCCTTTTGAGGTAAAAATAC
CGAACAAAGAGACAAGAGAGGCCATGGCAGAGCTGGAATCAGGAAAAGGCGAGCGATTTAAAACAATGAAGGATGTATGG
GATTCTGTAGATAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A5E8JFT0

References