Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1596846..1597687 Replicon chromosome
Accession NZ_CP062804
Organism Cupriavidus basilensis strain DSM 11853

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag F7R26_RS27960 Protein ID WP_150984583.1
Coordinates 1597172..1597687 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag F7R26_RS27955 Protein ID WP_150984584.1
Coordinates 1596846..1597175 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R26_RS27935 1591948..1593789 - 1842 WP_150984588.1 carboxylesterase family protein -
F7R26_RS27940 1593934..1594773 + 840 WP_150984587.1 transporter substrate-binding domain-containing protein -
F7R26_RS27945 1594896..1595543 - 648 WP_150984586.1 pyroglutamyl-peptidase I -
F7R26_RS27950 1595641..1596579 + 939 WP_150984585.1 LysR family transcriptional regulator -
F7R26_RS27955 1596846..1597175 + 330 WP_150984584.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
F7R26_RS27960 1597172..1597687 + 516 WP_150984583.1 type II toxin-antitoxin system YhaV family toxin Toxin
F7R26_RS27965 1597718..1598014 - 297 WP_150984582.1 XapX domain-containing protein -
F7R26_RS27970 1598079..1598519 - 441 WP_150984581.1 DoxX family protein -
F7R26_RS27975 1598562..1600427 - 1866 WP_150984690.1 amidohydrolase -
F7R26_RS27980 1600583..1601404 - 822 WP_150984689.1 alpha/beta hydrolase -
F7R26_RS27985 1601622..1602308 - 687 WP_150984580.1 hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19544.20 Da        Isoelectric Point: 10.0909

>T176627 WP_150984583.1 NZ_CP062804:1597172-1597687 [Cupriavidus basilensis]
MSAGRPAPLVINGWTVFAHPLFLAQLEGLTQQVEALKQRDPTGYVKKNASKRLAAISRLAFEVIAQDPARPEYRQGGTLG
DDHKHWFRAKFFQQYRLFFRYHAQSKVIVFAWVNDEDTKRAFESSDDAYRVFRKMLESGHPPDDWNQLLAEARAEGLRLQ
RMAAGAAQVQP

Download         Length: 516 bp

>T176627 NZ_CP082848:2778695-2778991 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11919.40 Da        Isoelectric Point: 4.4493

>AT176627 WP_150984584.1 NZ_CP062804:1596846-1597175 [Cupriavidus basilensis]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEASDGDDPVLGNFLNFLVSDIASHPERLQA
VDAGFVRRIQSLVGGIEVDLDAALLADDE

Download         Length: 330 bp

>AT176627 NZ_CP082848:2778451-2778705 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References