Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4946744..4947156 Replicon chromosome
Accession NZ_CP062782
Organism Escherichia coli O157:H7 strain Z869

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ35_RS25025 Protein ID WP_000132630.1
Coordinates 4946815..4947156 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4946744..4946820 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ35_RS25015 4943371..4944840 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ35_RS25020 4944840..4946594 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4946744..4946820 - 77 NuclAT_15 - Antitoxin
- 4946744..4946820 - 77 NuclAT_15 - Antitoxin
- 4946744..4946820 - 77 NuclAT_15 - Antitoxin
- 4946744..4946820 - 77 NuclAT_15 - Antitoxin
- 4946744..4946820 - 77 NuclAT_16 - Antitoxin
- 4946744..4946820 - 77 NuclAT_16 - Antitoxin
- 4946744..4946820 - 77 NuclAT_16 - Antitoxin
- 4946744..4946820 - 77 NuclAT_16 - Antitoxin
ILQ35_RS25025 4946815..4947156 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ35_RS25030 4947203..4948366 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ35_RS25035 4948414..4949295 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ35_RS25040 4949392..4949556 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ35_RS25045 4949733..4951145 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ35_RS25050 4951388..4951588 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4938943..4960164 21221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176592 WP_000132630.1 NZ_CP062782:4946815-4947156 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176592 NZ_CP082835:5331450-5331800 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 77 bp

>AT176592 NZ_CP062782:c4946820-4946744 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References