Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4598951..4599490 Replicon chromosome
Accession NZ_CP062782
Organism Escherichia coli O157:H7 strain Z869

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ35_RS23450 Protein ID WP_001303998.1
Coordinates 4599230..4599490 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ35_RS23445 Protein ID WP_000729705.1
Coordinates 4598951..4599211 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ35_RS23425 4594715..4595500 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ35_RS23430 4595472..4597184 + 1713 Protein_4587 flagellar biosynthesis protein FlhA -
ILQ35_RS23435 4597329..4597826 - 498 Protein_4588 REP-associated tyrosine transposase RayT -
ILQ35_RS23440 4598002..4598765 - 764 Protein_4589 C40 family peptidase -
ILQ35_RS23445 4598951..4599211 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ35_RS23450 4599230..4599490 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ35_RS23455 4599646..4600386 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ35_RS23460 4600357..4601124 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ35_RS23465 4601229..4601807 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 4592843..4614544 21701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T176590 WP_001303998.1 NZ_CP062782:4599230-4599490 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T176590 NZ_CP082835:c4466428-4466321 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT176590 WP_000729705.1 NZ_CP062782:4598951-4599211 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT176590 NZ_CP082835:4466476-4466542 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References