Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4822561..4822973 Replicon chromosome
Accession NZ_CP062780
Organism Escherichia coli O157:H7 strain Z1769

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ49_RS24165 Protein ID WP_000132630.1
Coordinates 4822632..4822973 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4822561..4822637 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ49_RS24155 4819188..4820657 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ49_RS24160 4820657..4822411 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4822561..4822637 - 77 NuclAT_14 - Antitoxin
- 4822561..4822637 - 77 NuclAT_14 - Antitoxin
- 4822561..4822637 - 77 NuclAT_14 - Antitoxin
- 4822561..4822637 - 77 NuclAT_14 - Antitoxin
- 4822561..4822637 - 77 NuclAT_15 - Antitoxin
- 4822561..4822637 - 77 NuclAT_15 - Antitoxin
- 4822561..4822637 - 77 NuclAT_15 - Antitoxin
- 4822561..4822637 - 77 NuclAT_15 - Antitoxin
ILQ49_RS24165 4822632..4822973 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ49_RS24170 4823020..4824183 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ49_RS24175 4824231..4825112 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ49_RS24180 4825209..4825373 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ49_RS24185 4825550..4826962 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ49_RS24190 4827205..4827405 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4814760..4835993 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176556 WP_000132630.1 NZ_CP062780:4822632-4822973 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176556 NZ_CP082833:c1117031-1116879 [Citrobacter rodentium NBRC 105723 = DSM 16636]
ATGCCGCAAAAATGTATATTATGCAGTTTAATAGTGATATGTCTCACTATATTATTATTTACCTGGATGGTTCGTGATTC
ATTATGCGAATTACATATCAGACAGGGCAATAATGAACTGGCGGCATTTTTAGCCTGTGAAGTGAAACAGTAA

Antitoxin


Download         Length: 77 bp

>AT176556 NZ_CP062780:c4822637-4822561 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References