Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4474787..4475326 Replicon chromosome
Accession NZ_CP062780
Organism Escherichia coli O157:H7 strain Z1769

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ49_RS22590 Protein ID WP_001303998.1
Coordinates 4475066..4475326 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ49_RS22585 Protein ID WP_000729705.1
Coordinates 4474787..4475047 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ49_RS22565 4470541..4471326 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ49_RS22570 4471298..4473010 + 1713 Protein_4418 flagellar biosynthesis protein FlhA -
ILQ49_RS22575 4473155..4473652 - 498 Protein_4419 REP-associated tyrosine transposase RayT -
ILQ49_RS22580 4473828..4474601 - 774 WP_000543891.1 C40 family peptidase -
ILQ49_RS22585 4474787..4475047 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ49_RS22590 4475066..4475326 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ49_RS22595 4475482..4476222 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ49_RS22600 4476193..4476960 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ49_RS22605 4477065..4477643 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T176554 WP_001303998.1 NZ_CP062780:4475066-4475326 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T176554 NZ_CP082833:c979141-978773 [Citrobacter rodentium NBRC 105723 = DSM 16636]
ATGAGTGTGCAATTTATCTCAGCGGAAGAGATAGTCCGGTTTCATGACAAACTGCTGAGCGTCACGCCCGGCGTAGCGGG
AATGCCGGATCCCGGGCGAGCGGAAGCTCTTTTGTATCGTGTCCTGAATAAGTATGAATACGAAGGCGTCACGGATGTCT
GGCTCCTTGCGGCCATGCATCTGTTGGCTATCTCCCGTGGTCATATTTTCAACGACGGCAATAAACGCACAGCCCTGTTC
ATCACCCTGCTTTTTCTCAAACGCAACGGCATTACGCTGAAGGCCAATCCGGATTTTGTGGCGATGACGGTCGAGGCTGC
TGCGGGTCGCTTATCCCTCGAAGAGATTGCTGAGCTTTTACGCCGCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT176554 WP_000729705.1 NZ_CP062780:4474787-4475047 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT176554 NZ_CP082833:c979359-979138 [Citrobacter rodentium NBRC 105723 = DSM 16636]
ATGCGTACAATGAACTATAGCGAAGCCCGCCAGAATCTTGCTTCCGCACTGGATTCTGCGGCTACCGGAACGCCAGTTAC
CATCACGCGTCGTGGGCATAAGCCCGCCGTCATCATCAGCGCCGAAGAGTTTGAACGCTATCAGGCAGCAAAACTGGATG
CGGAATTTGAGGCGATTATGGCGGTTCATGGAAATGAAATAAGGGAACTGGCTGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References