Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3324330..3325125 Replicon chromosome
Accession NZ_CP062778
Organism Escherichia coli O157:H7 strain Z1836

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ64_RS17065 Protein ID WP_000854914.1
Coordinates 3324330..3324704 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ILQ64_RS17070 Protein ID WP_001416641.1
Coordinates 3324751..3325125 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ64_RS17025 3319334..3319825 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ64_RS17030 3319927..3320481 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ64_RS17035 3320505..3321242 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ64_RS17040 3321297..3322235 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ64_RS17050 3322706..3323548 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ64_RS17055 3323633..3323830 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ64_RS17060 3323842..3324333 - 492 WP_000976853.1 hypothetical protein -
ILQ64_RS17065 3324330..3324704 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ64_RS17070 3324751..3325125 - 375 WP_001416641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ64_RS17075 3325288..3325509 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ64_RS17080 3325572..3326048 - 477 WP_001415969.1 RadC family protein -
ILQ64_RS17085 3326064..3326549 - 486 WP_000214398.1 antirestriction protein -
ILQ64_RS17090 3326640..3327458 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ64_RS17095 3327798..3328868 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ64_RS17100 3328865..3329770 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3315716..3326549 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176511 WP_000854914.1 NZ_CP062778:c3324704-3324330 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176511 NZ_CP082827:2176147-2176250 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13778.61 Da        Isoelectric Point: 6.6249

>AT176511 WP_001416641.1 NZ_CP062778:c3325125-3324751 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGFCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176511 NZ_CP082827:c2176288-2176017 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure

References