176434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3405061..3405856 Replicon chromosome
Accession NZ_CP062771
Organism Escherichia coli O157:H7 strain Z570

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ32_RS17595 Protein ID WP_000854914.1
Coordinates 3405061..3405435 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ32_RS17600 Protein ID WP_001280954.1
Coordinates 3405482..3405856 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ32_RS17555 3400065..3400556 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ32_RS17560 3400658..3401212 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ32_RS17565 3401236..3401973 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ32_RS17570 3402028..3402966 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ32_RS17580 3403437..3404279 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ32_RS17585 3404364..3404561 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ32_RS17590 3404573..3405064 - 492 WP_000976853.1 hypothetical protein -
ILQ32_RS17595 3405061..3405435 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ32_RS17600 3405482..3405856 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ32_RS17605 3406019..3406240 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ32_RS17610 3406303..3406779 - 477 WP_001186738.1 RadC family protein -
ILQ32_RS17615 3406795..3407280 - 486 WP_000214398.1 antirestriction protein -
ILQ32_RS17620 3407371..3408189 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ32_RS17625 3408529..3409599 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ32_RS17630 3409596..3410501 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgA / csgB / csgD / csgE / csgF / csgG 3395948..3407280 11332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176434 WP_000854914.1 NZ_CP062771:c3405435-3405061 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176434 NZ_CP082815:1871240-1871335 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176434 WP_001280954.1 NZ_CP062771:c3405856-3405482 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176434 NZ_CP082815:c1871420-1871363 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References