Detailed information of TA system TA176407

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4767735..4768147
• Replicon: chromosome
• Accession: NZ_CP062769
• Organism: Escherichia coli O157:H7 strain Z852

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: ILQ33_RS23785
• Protein ID: WP_000132630.1
• Coordinates: 4767806..4768147 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4767735..4767811 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ33_RS23775	4764362..4765831	+	1470	WP_001302468.1	type I restriction-modification system subunit M	-
ILQ33_RS23780	4765831..4767585	+	1755	WP_000110082.1	restriction endonuclease subunit S	-
-	4767735..4767811	-	77	NuclAT_14	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_14	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_14	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_14	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_15	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_15	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_15	-	Antitoxin
-	4767735..4767811	-	77	NuclAT_15	-	Antitoxin
ILQ33_RS23785	4767806..4768147	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
ILQ33_RS23790	4768194..4769357	-	1164	WP_001304006.1	DUF1524 domain-containing protein	-
ILQ33_RS23795	4769405..4770286	-	882	WP_001304007.1	DUF262 domain-containing protein	-
ILQ33_RS23800	4770383..4770547	-	165	WP_000394274.1	DUF1127 domain-containing protein	-
ILQ33_RS23805	4770724..4772136	+	1413	WP_000199295.1	PLP-dependent aminotransferase family protein	-
ILQ33_RS23810	4772379..4772579	-	201	WP_001310455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002655 Escherichia coli O157:H7 str. EDL933 5456776..5475497 0.003 View NC_002695 Escherichia coli O157:H7 str. Sakai 5426911..5445631 0.003	inside	Genomic island	-	espX6	4759934..4781161	21227

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T176407 WP_000132630.1 NZ_CP062769:4767806-4768147 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T176407 NZ_CP082805:732249-732734 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT176407 NZ_CP062769:c4767811-4767735 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin