Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4841800..4842212 Replicon chromosome
Accession NZ_CP062761
Organism Escherichia coli O157:H7 strain Z887

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ37_RS24275 Protein ID WP_000132630.1
Coordinates 4841871..4842212 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4841800..4841876 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ37_RS24265 4838427..4839896 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ37_RS24270 4839896..4841650 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4841800..4841876 - 77 NuclAT_14 - Antitoxin
- 4841800..4841876 - 77 NuclAT_14 - Antitoxin
- 4841800..4841876 - 77 NuclAT_14 - Antitoxin
- 4841800..4841876 - 77 NuclAT_14 - Antitoxin
- 4841800..4841876 - 77 NuclAT_15 - Antitoxin
- 4841800..4841876 - 77 NuclAT_15 - Antitoxin
- 4841800..4841876 - 77 NuclAT_15 - Antitoxin
- 4841800..4841876 - 77 NuclAT_15 - Antitoxin
ILQ37_RS24275 4841871..4842212 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ37_RS24280 4842259..4843422 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ37_RS24285 4843470..4844351 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ37_RS24290 4844448..4844612 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ37_RS24295 4844789..4846201 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ37_RS24300 4846444..4846644 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4833999..4855196 21197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176302 WP_000132630.1 NZ_CP062761:4841871-4842212 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176302 NZ_CP082776:c3660648-3660337 [Escherichia coli O4:H5]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 77 bp

>AT176302 NZ_CP062761:c4841876-4841800 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References