Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4815493..4815905 Replicon chromosome
Accession NZ_CP062758
Organism Escherichia coli O157:H7 strain Z892

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ38_RS24100 Protein ID WP_000132630.1
Coordinates 4815564..4815905 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4815493..4815569 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ38_RS24090 4812120..4813589 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ38_RS24095 4813589..4815343 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4815493..4815569 - 77 NuclAT_14 - Antitoxin
- 4815493..4815569 - 77 NuclAT_14 - Antitoxin
- 4815493..4815569 - 77 NuclAT_14 - Antitoxin
- 4815493..4815569 - 77 NuclAT_14 - Antitoxin
- 4815493..4815569 - 77 NuclAT_15 - Antitoxin
- 4815493..4815569 - 77 NuclAT_15 - Antitoxin
- 4815493..4815569 - 77 NuclAT_15 - Antitoxin
- 4815493..4815569 - 77 NuclAT_15 - Antitoxin
ILQ38_RS24100 4815564..4815905 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ38_RS24105 4815952..4817115 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ38_RS24110 4817163..4818044 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ38_RS24115 4818141..4818305 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ38_RS24120 4818482..4819894 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ38_RS24125 4820137..4820337 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4807692..4828919 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176264 WP_000132630.1 NZ_CP062758:4815564-4815905 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176264 NZ_CP082774:c3040967-3040713 [Escherichia coli O16:H6]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCACTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 77 bp

>AT176264 NZ_CP062758:c4815569-4815493 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References