Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2580507..2580978 Replicon chromosome
Accession NZ_CP062758
Organism Escherichia coli O157:H7 strain Z892

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ILQ38_RS12995 Protein ID WP_001303511.1
Coordinates 2580507..2580785 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ILQ38_RS13000 Protein ID WP_001302048.1
Coordinates 2580787..2580978 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ38_RS12960 2575513..2575697 - 185 Protein_2530 DUF3596 domain-containing protein -
ILQ38_RS12965 2575732..2575983 - 252 WP_000005552.1 excisionase family protein -
ILQ38_RS12970 2576056..2578527 - 2472 WP_000048458.1 exonuclease -
ILQ38_RS12975 2578620..2578811 - 192 WP_001090200.1 DUF1482 family protein -
ILQ38_RS12980 2578808..2578996 - 189 WP_000449192.1 cell division inhibition protein DicB -
ILQ38_RS12985 2579565..2579783 - 219 WP_001171930.1 hypothetical protein -
ILQ38_RS12990 2579855..2580154 - 300 WP_001240334.1 hypothetical protein -
ILQ38_RS12995 2580507..2580785 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ38_RS13000 2580787..2580978 - 192 WP_001302048.1 hypothetical protein Antitoxin
ILQ38_RS13005 2580999..2581370 - 372 WP_001169686.1 hypothetical protein -
ILQ38_RS13010 2581468..2581770 + 303 WP_000172738.1 transcriptional regulator -
ILQ38_RS13015 2581767..2582192 + 426 WP_000693943.1 Rha family transcriptional regulator -
ILQ38_RS13020 2582215..2583177 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
ILQ38_RS13025 2583184..2583924 + 741 WP_000788938.1 ATP-binding protein -
ILQ38_RS13030 2583950..2584719 + 770 Protein_2544 DUF1627 domain-containing protein -
ILQ38_RS13035 2584735..2585130 + 396 WP_001118159.1 DUF977 family protein -
ILQ38_RS13040 2585187..2585771 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 2565627..2622055 56428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T176251 WP_001303511.1 NZ_CP062758:c2580785-2580507 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T176251 NZ_CP082774:175782-176093 [Escherichia coli O16:H6]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT176251 WP_001302048.1 NZ_CP062758:c2580978-2580787 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT176251 NZ_CP082774:176094-176384 [Escherichia coli O16:H6]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References