Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2580507..2580978 | Replicon | chromosome |
Accession | NZ_CP062758 | ||
Organism | Escherichia coli O157:H7 strain Z892 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | ILQ38_RS12995 | Protein ID | WP_001303511.1 |
Coordinates | 2580507..2580785 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | ILQ38_RS13000 | Protein ID | WP_001302048.1 |
Coordinates | 2580787..2580978 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ILQ38_RS12960 | 2575513..2575697 | - | 185 | Protein_2530 | DUF3596 domain-containing protein | - |
ILQ38_RS12965 | 2575732..2575983 | - | 252 | WP_000005552.1 | excisionase family protein | - |
ILQ38_RS12970 | 2576056..2578527 | - | 2472 | WP_000048458.1 | exonuclease | - |
ILQ38_RS12975 | 2578620..2578811 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
ILQ38_RS12980 | 2578808..2578996 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
ILQ38_RS12985 | 2579565..2579783 | - | 219 | WP_001171930.1 | hypothetical protein | - |
ILQ38_RS12990 | 2579855..2580154 | - | 300 | WP_001240334.1 | hypothetical protein | - |
ILQ38_RS12995 | 2580507..2580785 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ILQ38_RS13000 | 2580787..2580978 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
ILQ38_RS13005 | 2580999..2581370 | - | 372 | WP_001169686.1 | hypothetical protein | - |
ILQ38_RS13010 | 2581468..2581770 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
ILQ38_RS13015 | 2581767..2582192 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
ILQ38_RS13020 | 2582215..2583177 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
ILQ38_RS13025 | 2583184..2583924 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
ILQ38_RS13030 | 2583950..2584719 | + | 770 | Protein_2544 | DUF1627 domain-containing protein | - |
ILQ38_RS13035 | 2584735..2585130 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
ILQ38_RS13040 | 2585187..2585771 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | nleA/espI | 2565627..2622055 | 56428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176251 WP_001303511.1 NZ_CP062758:c2580785-2580507 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176251 NZ_CP082774:175782-176093 [Escherichia coli O16:H6]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176251 WP_001302048.1 NZ_CP062758:c2580978-2580787 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176251 NZ_CP082774:176094-176384 [Escherichia coli O16:H6]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 5CZF | |
PDB | 5CW7 | |
PDB | 5CZE |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CTP0 |