Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3369580..3370375 Replicon chromosome
Accession NZ_CP062755
Organism Escherichia coli O157:H7 strain Z903

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ39_RS17315 Protein ID WP_000854914.1
Coordinates 3369580..3369954 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ39_RS17320 Protein ID WP_001280954.1
Coordinates 3370001..3370375 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ39_RS17275 3364584..3365075 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ39_RS17280 3365177..3365731 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ39_RS17285 3365755..3366492 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ39_RS17290 3366547..3367485 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ39_RS17300 3367956..3368798 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ39_RS17305 3368883..3369080 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ39_RS17310 3369092..3369583 - 492 WP_000976853.1 hypothetical protein -
ILQ39_RS17315 3369580..3369954 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ39_RS17320 3370001..3370375 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ39_RS17325 3370538..3370759 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ39_RS17330 3370822..3371298 - 477 WP_001186738.1 RadC family protein -
ILQ39_RS17335 3371314..3371799 - 486 WP_000214398.1 antirestriction protein -
ILQ39_RS17340 3371890..3372708 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ39_RS17345 3373048..3374118 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ39_RS17350 3374115..3375020 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3360966..3371799 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176219 WP_000854914.1 NZ_CP062755:c3369954-3369580 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176219 NZ_CP082772:3036420-3036707 [Escherichia coli O2:H1]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176219 WP_001280954.1 NZ_CP062755:c3370375-3370001 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176219 NZ_CP082772:3036229-3036420 [Escherichia coli O2:H1]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References