Detailed information of TA system TA176208

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2462633..2462858
• Replicon: chromosome
• Accession: NZ_CP062755
• Organism: Escherichia coli O157:H7 strain Z903

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: ILQ39_RS12210
• Protein ID: WP_000813258.1
• Coordinates: 2462633..2462788 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2462800..2462858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ39_RS12160	2457636..2458067	-	432	WP_001302123.1	tellurite resistance protein	-
ILQ39_RS12175	2458518..2459231	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
ILQ39_RS12180	2459367..2459564	-	198	WP_000917763.1	hypothetical protein	-
ILQ39_RS12185	2459789..2460343	-	555	WP_000640035.1	DUF1133 family protein	-
ILQ39_RS12190	2460406..2460711	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ39_RS12195	2460724..2461773	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
ILQ39_RS12200	2461775..2462047	-	273	WP_000191872.1	hypothetical protein	-
ILQ39_RS12205	2462169..2462513	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
ILQ39_RS12210	2462633..2462788	-	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2462800..2462858	+	59	-	-	Antitoxin
ILQ39_RS12215	2463079..2463636	-	558	WP_000104474.1	DUF551 domain-containing protein	-
ILQ39_RS12220	2463638..2463856	-	219	WP_000683609.1	DUF4014 family protein	-
ILQ39_RS12225	2463984..2464295	-	312	WP_001289673.1	hypothetical protein	-
ILQ39_RS12230	2464288..2464515	-	228	WP_000699809.1	hypothetical protein	-
ILQ39_RS12235	2464512..2464793	-	282	WP_000603384.1	DNA-binding protein	-
ILQ39_RS12240	2464826..2465542	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
ILQ39_RS12245	2465576..2466037	-	462	WP_000139447.1	replication protein	-
ILQ39_RS12250	2466030..2467073	-	1044	WP_001262402.1	hypothetical protein	-
ILQ39_RS12255	2467142..2467567	-	426	WP_000693878.1	Rha family transcriptional regulator	-
ILQ39_RS12260	2467551..2467793	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleC / nleG7' / paa	2378407..2525028	146621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T176208 WP_000813258.1 NZ_CP062755:c2462788-2462633 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T176208 NZ_CP082772:482737-482910 [Escherichia coli O2:H1]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT176208 NZ_CP062755:2462800-2462858 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin