Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4813237..4813649 Replicon chromosome
Accession NZ_CP062752
Organism Escherichia coli O157:H7 strain Z910

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ40_RS24080 Protein ID WP_000132630.1
Coordinates 4813308..4813649 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4813237..4813313 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ40_RS24070 4809864..4811333 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ40_RS24075 4811333..4813087 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4813237..4813313 - 77 NuclAT_14 - Antitoxin
- 4813237..4813313 - 77 NuclAT_14 - Antitoxin
- 4813237..4813313 - 77 NuclAT_14 - Antitoxin
- 4813237..4813313 - 77 NuclAT_14 - Antitoxin
- 4813237..4813313 - 77 NuclAT_15 - Antitoxin
- 4813237..4813313 - 77 NuclAT_15 - Antitoxin
- 4813237..4813313 - 77 NuclAT_15 - Antitoxin
- 4813237..4813313 - 77 NuclAT_15 - Antitoxin
ILQ40_RS24080 4813308..4813649 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ40_RS24085 4813696..4814859 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ40_RS24090 4814907..4815788 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ40_RS24095 4815885..4816049 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ40_RS24100 4816226..4817638 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ40_RS24105 4817881..4818081 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4805436..4826663 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176192 WP_000132630.1 NZ_CP062752:4813308-4813649 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176192 NZ_CP082771:c816638-816486 [Escherichia coli LF82]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 77 bp

>AT176192 NZ_CP062752:c4813313-4813237 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References