Detailed information of TA system TA176162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 283265..283486
• Replicon: chromosome
• Accession: NZ_CP062752
• Organism: Escherichia coli O157:H7 strain Z910

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ILQ40_RS01345
• Protein ID: WP_001295224.1
• Coordinates: 283379..283486 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	283265..283330 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ40_RS01325	278705..279607	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
ILQ40_RS01330	279618..280601	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ILQ40_RS01335	280598..281602	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ILQ40_RS01340	281632..282903	-	1272	WP_001301684.1	amino acid permease	-
-	283265..283330	-	66	NuclAT_16	-	Antitoxin
-	283265..283330	-	66	NuclAT_16	-	Antitoxin
-	283265..283330	-	66	NuclAT_16	-	Antitoxin
-	283265..283330	-	66	NuclAT_16	-	Antitoxin
-	283265..283330	-	66	NuclAT_21	-	Antitoxin
-	283265..283330	-	66	NuclAT_21	-	Antitoxin
-	283265..283330	-	66	NuclAT_21	-	Antitoxin
-	283265..283330	-	66	NuclAT_21	-	Antitoxin
ILQ40_RS01345	283379..283486	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
ILQ40_RS01350	283573..285252	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ILQ40_RS01355	285249..285440	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ILQ40_RS01360	285437..287008	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ILQ40_RS01365	287281..287469	+	189	WP_001063316.1	YhjR family protein	-
ILQ40_RS01370	287481..287678	+	198	WP_000279508.1	AAA family ATPase	-
ILQ40_RS01375	287697..288233	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T176162 WP_001295224.1 NZ_CP062752:283379-283486 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T176162 NZ_CP082759:c5076112-5075195 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT176162 NZ_CP062752:c283330-283265 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin