Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4825005..4825417 Replicon chromosome
Accession NZ_CP062749
Organism Escherichia coli O157:H7 strain Z1486

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ41_RS24150 Protein ID WP_000132630.1
Coordinates 4825076..4825417 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4825005..4825081 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ41_RS24140 4821632..4823101 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ41_RS24145 4823101..4824855 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4825005..4825081 - 77 NuclAT_14 - Antitoxin
- 4825005..4825081 - 77 NuclAT_14 - Antitoxin
- 4825005..4825081 - 77 NuclAT_14 - Antitoxin
- 4825005..4825081 - 77 NuclAT_14 - Antitoxin
- 4825005..4825081 - 77 NuclAT_15 - Antitoxin
- 4825005..4825081 - 77 NuclAT_15 - Antitoxin
- 4825005..4825081 - 77 NuclAT_15 - Antitoxin
- 4825005..4825081 - 77 NuclAT_15 - Antitoxin
ILQ41_RS24150 4825076..4825417 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ41_RS24155 4825464..4826627 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ41_RS24160 4826675..4827556 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ41_RS24165 4827653..4827817 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ41_RS24170 4827994..4829406 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ41_RS24175 4829649..4829849 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4817204..4838443 21239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176156 WP_000132630.1 NZ_CP062749:4825076-4825417 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176156 NZ_CP082759:879152-879559 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 77 bp

>AT176156 NZ_CP062749:c4825081-4825005 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References