Detailed information of TA system TA176102

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3062703..3062928
• Replicon: chromosome
• Accession: NZ_CP062746
• Organism: Escherichia coli O157:H7 strain Z1504

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: ILQ42_RS15565
• Protein ID: WP_000813258.1
• Coordinates: 3062703..3062858 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3062870..3062928 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ42_RS15515	3057706..3058137	-	432	WP_001302123.1	tellurite resistance protein	-
ILQ42_RS15530	3058588..3059301	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
ILQ42_RS15535	3059437..3059634	-	198	WP_000917763.1	hypothetical protein	-
ILQ42_RS15540	3059859..3060413	-	555	WP_000640035.1	DUF1133 family protein	-
ILQ42_RS15545	3060476..3060781	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ42_RS15550	3060794..3061843	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
ILQ42_RS15555	3061845..3062117	-	273	WP_000191872.1	hypothetical protein	-
ILQ42_RS15560	3062239..3062583	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
ILQ42_RS15565	3062703..3062858	-	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3062870..3062928	+	59	-	-	Antitoxin
ILQ42_RS15570	3063149..3063706	-	558	WP_000104474.1	DUF551 domain-containing protein	-
ILQ42_RS15575	3063708..3063926	-	219	WP_000683609.1	DUF4014 family protein	-
ILQ42_RS15580	3064054..3064365	-	312	WP_001289673.1	hypothetical protein	-
ILQ42_RS15585	3064358..3064585	-	228	WP_000699809.1	hypothetical protein	-
ILQ42_RS15590	3064582..3064863	-	282	WP_000603384.1	DNA-binding protein	-
ILQ42_RS15595	3064896..3065612	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
ILQ42_RS15600	3065646..3066107	-	462	WP_000139447.1	replication protein	-
ILQ42_RS15605	3066100..3067143	-	1044	WP_001262402.1	hypothetical protein	-
ILQ42_RS15610	3067212..3067637	-	426	WP_000693878.1	Rha family transcriptional regulator	-
ILQ42_RS15615	3067621..3067863	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleC / nleG7' / paa	2979796..3132322	152526

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T176102 WP_000813258.1 NZ_CP062746:c3062858-3062703 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T176102 NZ_CP082356:c19015-18599 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT176102 NZ_CP062746:3062870-3062928 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin