Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2341063..2341858 Replicon chromosome
Accession NZ_CP062746
Organism Escherichia coli O157:H7 strain Z1504

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ42_RS11690 Protein ID WP_000854914.1
Coordinates 2341484..2341858 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ42_RS11685 Protein ID WP_001280954.1
Coordinates 2341063..2341437 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ42_RS11655 2336418..2337323 + 906 WP_000203541.1 chemotaxis protein -
ILQ42_RS11660 2337320..2338390 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ42_RS11665 2338730..2339548 + 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ42_RS11670 2339639..2340124 + 486 WP_000214398.1 antirestriction protein -
ILQ42_RS11675 2340140..2340616 + 477 WP_001186738.1 RadC family protein -
ILQ42_RS11680 2340679..2340900 + 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ42_RS11685 2341063..2341437 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ42_RS11690 2341484..2341858 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ42_RS11695 2341855..2342346 + 492 WP_000976853.1 hypothetical protein -
ILQ42_RS11700 2342358..2342555 + 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ42_RS11705 2342640..2343482 + 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ42_RS11715 2343953..2344888 + 936 Protein_2286 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ42_RS11720 2344963..2345700 + 738 WP_000283664.1 zinc-binding phosphatase -
ILQ42_RS11725 2345724..2346278 + 555 WP_001001917.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2340140..2352439 12299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176097 WP_000854914.1 NZ_CP062746:2341484-2341858 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176097 NZ_CP082355:4024317-4024469 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176097 WP_001280954.1 NZ_CP062746:2341063-2341437 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176097 NZ_CP082355:c4024268-4024211 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References