Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4824999..4825411 | Replicon | chromosome |
Accession | NZ_CP062744 | ||
Organism | Escherichia coli O157:H7 strain Z1615 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | ILQ43_RS24185 | Protein ID | WP_000132630.1 |
Coordinates | 4825070..4825411 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4824999..4825075 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ILQ43_RS24175 | 4821626..4823095 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
ILQ43_RS24180 | 4823095..4824849 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4824999..4825075 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4824999..4825075 | - | 77 | NuclAT_15 | - | Antitoxin |
ILQ43_RS24185 | 4825070..4825411 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
ILQ43_RS24190 | 4825458..4826621 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
ILQ43_RS24195 | 4826669..4827550 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
ILQ43_RS24200 | 4827647..4827811 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
ILQ43_RS24205 | 4827988..4829400 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
ILQ43_RS24210 | 4829643..4829843 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4817198..4838431 | 21233 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T176082 WP_000132630.1 NZ_CP062744:4825070-4825411 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T176082 NZ_CP082353:11438-11719 [Providencia rettgeri]
ATGATCTATAAACTTGAATTCGATAAGCGTGCGTTAAAAGAATGGCAAAAATTGGCTCCCCCGATTAGAAATCAATTTAA
AAAGAAATTAGCAGAGCGTCTTGAAAACCCCTTTGTTCCATCAGCTCAACTGAGTGGTAAACACAATCGTTATAAAATAA
AACTACGGTCATTAGGCTACCGCTTAGTTTATGAGGTAGTTGATGAGAAAATTGTTTTGTTGGTCATTGCGGTTGGCAAA
AGAGAGGGAAACGCTATCTACTTTTCGTCGAACGAACGTTAA
ATGATCTATAAACTTGAATTCGATAAGCGTGCGTTAAAAGAATGGCAAAAATTGGCTCCCCCGATTAGAAATCAATTTAA
AAAGAAATTAGCAGAGCGTCTTGAAAACCCCTTTGTTCCATCAGCTCAACTGAGTGGTAAACACAATCGTTATAAAATAA
AACTACGGTCATTAGGCTACCGCTTAGTTTATGAGGTAGTTGATGAGAAAATTGTTTTGTTGGTCATTGCGGTTGGCAAA
AGAGAGGGAAACGCTATCTACTTTTCGTCGAACGAACGTTAA
Antitoxin
Download Length: 77 bp
>AT176082 NZ_CP062744:c4825075-4824999 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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