Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2344953..2345748 Replicon chromosome
Accession NZ_CP062744
Organism Escherichia coli O157:H7 strain Z1615

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ43_RS11720 Protein ID WP_000854914.1
Coordinates 2345374..2345748 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ43_RS11715 Protein ID WP_001280954.1
Coordinates 2344953..2345327 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ43_RS11685 2340308..2341213 + 906 WP_000203541.1 chemotaxis protein -
ILQ43_RS11690 2341210..2342280 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ43_RS11695 2342620..2343438 + 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ43_RS11700 2343529..2344014 + 486 WP_000214398.1 antirestriction protein -
ILQ43_RS11705 2344030..2344506 + 477 WP_001186738.1 RadC family protein -
ILQ43_RS11710 2344569..2344790 + 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ43_RS11715 2344953..2345327 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ43_RS11720 2345374..2345748 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ43_RS11725 2345745..2346236 + 492 WP_000976853.1 hypothetical protein -
ILQ43_RS11730 2346248..2346445 + 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ43_RS11735 2346530..2347372 + 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ43_RS11745 2347843..2348781 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ43_RS11750 2348836..2349573 + 738 WP_000283664.1 zinc-binding phosphatase -
ILQ43_RS11755 2349597..2350151 + 555 WP_001001917.1 molecular chaperone YcdY -
ILQ43_RS11760 2350253..2350744 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2344030..2356312 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176059 WP_000854914.1 NZ_CP062744:2345374-2345748 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176059 NZ_CP082349:1035433-1035768 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176059 WP_001280954.1 NZ_CP062744:2344953-2345327 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176059 NZ_CP082349:1035185-1035433 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References