Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4477286..4477825 Replicon chromosome
Accession NZ_CP062742
Organism Escherichia coli O157:H7 strain Z1626

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ44_RS22570 Protein ID WP_001303998.1
Coordinates 4477565..4477825 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ44_RS22565 Protein ID WP_000729705.1
Coordinates 4477286..4477546 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ44_RS22545 4473040..4473825 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ44_RS22550 4473797..4475509 + 1713 Protein_4414 flagellar biosynthesis protein FlhA -
ILQ44_RS22555 4475654..4476151 - 498 Protein_4415 REP-associated tyrosine transposase RayT -
ILQ44_RS22560 4476327..4477100 - 774 WP_000543891.1 C40 family peptidase -
ILQ44_RS22565 4477286..4477546 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ44_RS22570 4477565..4477825 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ44_RS22575 4477981..4478721 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ44_RS22580 4478692..4479459 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ44_RS22585 4479564..4480142 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T176042 WP_001303998.1 NZ_CP062742:4477565-4477825 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T176042 NZ_CP082346:634698-635069 [Pantoea dispersa]
ATGCAAACCTTATCATCACACCTGACACGGGCGGCTAAGAGCTGTCTGTCACCCGTTGAAATCTGGCAGCGGTTACTGAC
TCATCTGTTGTCGCAGCACTATGGTCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACTGGAACACATTG
ATGCTGGAGTATCGCTCTGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGTGAGAATTGACTGTAATGATTGC
TCTGTCATGGAGAAGTCACCGTTCATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCTGGTCTGATGAAACGCAG
CGATCACAAAACTGTTACCAGGGTAACGGCAGGTCATCATCAGGAGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT176042 WP_000729705.1 NZ_CP062742:4477286-4477546 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT176042 NZ_CP082346:634294-634659 [Pantoea dispersa]
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTACAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTTCAGGAAGGCAACTGCCTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACGATGAGGCGTTGCACCTGGATCAGGCCTTTCTGTTGATACTCAAACAACTGGAGCTGATGCTTACCAGCGGAGAA
CTCTCTCCCCGGCATCAGCACTGCGTCACGCTATATCACAATGGACTTACTTGCGAAGCAGACACACTCGGCTCCTGCGG
CTATGTCTACATTGCTATCTATCCTGATCAGATTGAGTTCCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References