Detailed information of TA system TA176036

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3584563..3584788
• Replicon: chromosome
• Accession: NZ_CP062742
• Organism: Escherichia coli O157:H7 strain Z1626

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: ILQ44_RS18415
• Protein ID: WP_000813263.1
• Coordinates: 3584563..3584718 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3584730..3584788 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ44_RS18380	3580017..3580730	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
ILQ44_RS18385	3580868..3581064	-	197	Protein_3598	TrmB family transcriptional regulator	-
ILQ44_RS18390	3581351..3582169	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
ILQ44_RS18395	3582321..3582692	-	372	WP_000090264.1	antitermination protein	-
ILQ44_RS18400	3582682..3583053	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ44_RS18405	3583066..3584115	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
ILQ44_RS18410	3584117..3584395	-	279	WP_001341388.1	hypothetical protein	-
ILQ44_RS18415	3584563..3584718	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3584730..3584788	+	59	-	-	Antitoxin
ILQ44_RS18420	3585323..3586096	+	774	WP_000160654.1	alpha/beta hydrolase	-
ILQ44_RS18425	3586448..3586861	-	414	WP_001151233.1	DUF977 family protein	-
ILQ44_RS18430	3586877..3587647	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ44_RS18435	3587669..3588415	-	747	WP_000788751.1	ATP-binding protein	-
ILQ44_RS18440	3588422..3589513	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T176036 WP_000813263.1 NZ_CP062742:c3584718-3584563 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T176036 NZ_CP082342:242610-242954 [Pantoea dispersa]
ATGCAAGCGACGTTTATTGAGCTTTCCAGCTTTCAGAAATACCGGGCAGATTACCTGAGCGACGATCAATTCAGGCTGTT
TCAGAATATGTTGCTGGCCGACCCCGAAAAGGGCGACATCATTCCCGATACGGGCGGGCTTCGTAAAGTTCGTTTCAGGG
ATGAACGCCGGAACAAGGGATCGCGGGGCGGGATTAGAATTATCTATTACTGGACGAATGAAAAAGGCCAGTTCATCCTG
TTCAGCATATATAATAAAGATCAACGCGACGATCTGACCAAACAACAGCGCGATGCCCTGGCGGAGGCGCTGAACGTGAT
CAAAAAGGGGCTGAGACATGACTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT176036 NZ_CP062742:3584730-3584788 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin