176035

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3368282..3369077 Replicon chromosome
Accession NZ_CP062742
Organism Escherichia coli O157:H7 strain Z1626

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ44_RS17310 Protein ID WP_000854914.1
Coordinates 3368282..3368656 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ44_RS17315 Protein ID WP_001280954.1
Coordinates 3368703..3369077 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ44_RS17270 3363286..3363777 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ44_RS17275 3363879..3364433 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ44_RS17280 3364457..3365194 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ44_RS17285 3365249..3366187 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ44_RS17295 3366658..3367500 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ44_RS17300 3367585..3367782 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ44_RS17305 3367794..3368285 - 492 WP_000976853.1 hypothetical protein -
ILQ44_RS17310 3368282..3368656 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ44_RS17315 3368703..3369077 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ44_RS17320 3369240..3369461 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ44_RS17325 3369524..3370000 - 477 WP_001186738.1 RadC family protein -
ILQ44_RS17330 3370016..3370501 - 486 WP_000214398.1 antirestriction protein -
ILQ44_RS17335 3370592..3371410 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ44_RS17340 3371750..3372820 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ44_RS17345 3372817..3373722 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3359668..3370501 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176035 WP_000854914.1 NZ_CP062742:c3368656-3368282 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176035 NZ_CP082342:c64714-64424 [Pantoea dispersa]
ATGACTTATAAATTAAAGTTCGTTCCTTCCGCTGAAAAGGAATGGAAGAAACTGGGTCATCCGGTGCGTGAGCAGTTTAA
GAAAAAGCTGGCACAACGGCTGGAAAATCCCCGTGTCCCCTCAGCACAACTTCACGGACGAAAAGATCAGTACAAAATAA
AACTACGTGCTTCAGGCTATCGCCTGGTGTACCTGGTGCAGGATGAAACCATCACTGTCATGGTATTAGGTGTGGGTAAA
CGCGAAGGCAGCCAGGTCTATGTTGATACGGAATGCAGGGTGCCTGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176035 WP_001280954.1 NZ_CP062742:c3369077-3368703 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176035 NZ_CP082342:c64958-64704 [Pantoea dispersa]
ATGCCATTTCAGATCCTGTCAAACACCGCTGCCAGTATTACCGATTTAAAGCGTGATCCCATGGGAACAGTGCGTTCAGC
GGAAGGGGAAACCATCGCCATTTTAAACCGCAACGAGCCCGCTTTTTACTGCGTTCCACCGGCTGTTTACCAATATCTGA
TGGAATTAGCAGAAGATGCAGAACTGGGTCGTATCGCTGATGAACGCATTTCTGAATTAGCGGATGCGAAAGAGATTTCG
CTGGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References