Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 709721..710520 Replicon chromosome
Accession NZ_CP062742
Organism Escherichia coli O157:H7 strain Z1626

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag ILQ44_RS03465 Protein ID WP_000347273.1
Coordinates 709721..710185 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag ILQ44_RS03470 Protein ID WP_001302819.1
Coordinates 710185..710520 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ44_RS03435 704722..705156 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
ILQ44_RS03440 705174..706052 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ILQ44_RS03445 706042..706821 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ILQ44_RS03450 706832..707305 - 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
ILQ44_RS03455 707328..708608 - 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
ILQ44_RS03460 708857..709666 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ILQ44_RS03465 709721..710185 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ILQ44_RS03470 710185..710520 - 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ILQ44_RS03475 710669..712240 - 1572 WP_001273776.1 galactarate dehydratase -
ILQ44_RS03480 712615..713949 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ILQ44_RS03485 713965..714735 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T176019 WP_000347273.1 NZ_CP062742:c710185-709721 [Escherichia coli O157:H7]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T176019 NZ_CP082338:1956305-1956408 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT176019 WP_001302819.1 NZ_CP062742:c710520-710185 [Escherichia coli O157:H7]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT176019 NZ_CP082338:c1956410-1956265 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References