Detailed information of TA system TA176014

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 284578..284799
• Replicon: chromosome
• Accession: NZ_CP062742
• Organism: Escherichia coli O157:H7 strain Z1626

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ILQ44_RS01350
• Protein ID: WP_001295224.1
• Coordinates: 284692..284799 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	284578..284643 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ44_RS01330	280018..280920	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
ILQ44_RS01335	280931..281914	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ILQ44_RS01340	281911..282915	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ILQ44_RS01345	282945..284216	-	1272	WP_206384805.1	transporter	-
-	284578..284643	-	66	NuclAT_16	-	Antitoxin
-	284578..284643	-	66	NuclAT_16	-	Antitoxin
-	284578..284643	-	66	NuclAT_16	-	Antitoxin
-	284578..284643	-	66	NuclAT_16	-	Antitoxin
-	284578..284643	-	66	NuclAT_21	-	Antitoxin
-	284578..284643	-	66	NuclAT_21	-	Antitoxin
-	284578..284643	-	66	NuclAT_21	-	Antitoxin
-	284578..284643	-	66	NuclAT_21	-	Antitoxin
ILQ44_RS01350	284692..284799	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
ILQ44_RS01355	284886..286565	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ILQ44_RS01360	286562..286753	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ILQ44_RS01365	286750..288321	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ILQ44_RS01370	288594..288782	+	189	WP_001063316.1	YhjR family protein	-
ILQ44_RS01375	288794..288991	+	198	WP_000279508.1	AAA family ATPase	-
ILQ44_RS01380	289010..289546	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T176014 WP_001295224.1 NZ_CP062742:284692-284799 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T176014 NZ_CP082334:91868-92137 [Exiguobacterium acetylicum]
ATGACAGCATTTACGGTAGAGTTTGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGACCCTCAACAAGCGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGTAAAGGGCTTGTCTCGAACAGATCGG
GTGAATGGCGGTATCGCATCGGTGATTATCGTCTGATTGCTGACATTCAAGATGAAAAAGTCGTGATTTTGATTCTCGAG
ATCGGGCATCGTCGAGATATTTACAAATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT176014 NZ_CP062742:c284643-284578 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin