Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 5035789..5036201 Replicon chromosome
Accession NZ_CP062739
Organism Escherichia coli O157:H7 strain Z1723

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ45_RS25400 Protein ID WP_000132630.1
Coordinates 5035860..5036201 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 5035789..5035865 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ45_RS25390 5032416..5033885 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ45_RS25395 5033885..5035639 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 5035789..5035865 - 77 NuclAT_14 - Antitoxin
- 5035789..5035865 - 77 NuclAT_14 - Antitoxin
- 5035789..5035865 - 77 NuclAT_14 - Antitoxin
- 5035789..5035865 - 77 NuclAT_14 - Antitoxin
- 5035789..5035865 - 77 NuclAT_15 - Antitoxin
- 5035789..5035865 - 77 NuclAT_15 - Antitoxin
- 5035789..5035865 - 77 NuclAT_15 - Antitoxin
- 5035789..5035865 - 77 NuclAT_15 - Antitoxin
ILQ45_RS25400 5035860..5036201 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ45_RS25405 5036248..5037411 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ45_RS25410 5037459..5038340 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ45_RS25415 5038437..5038601 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ45_RS25420 5038778..5040190 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ45_RS25425 5040433..5040633 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 5027988..5049221 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T176008 WP_000132630.1 NZ_CP062739:5035860-5036201 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T176008 NZ_CP082327:c3640674-3640276 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 77 bp

>AT176008 NZ_CP062739:c5035865-5035789 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References