Detailed information of TA system TA175962

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3572718..3572943
• Replicon: chromosome
• Accession: NZ_CP062736
• Organism: Escherichia coli O157:H7 strain Z1766

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: ILQ46_RS18355
• Protein ID: WP_000813263.1
• Coordinates: 3572718..3572873 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3572885..3572943 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ46_RS18320	3568172..3568885	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
ILQ46_RS18325	3569023..3569219	-	197	Protein_3586	TrmB family transcriptional regulator	-
ILQ46_RS18330	3569506..3570324	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
ILQ46_RS18335	3570476..3570847	-	372	WP_000090264.1	antitermination protein	-
ILQ46_RS18340	3570837..3571208	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
ILQ46_RS18345	3571221..3572270	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
ILQ46_RS18350	3572272..3572550	-	279	WP_001341388.1	hypothetical protein	-
ILQ46_RS18355	3572718..3572873	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3572885..3572943	+	59	-	-	Antitoxin
ILQ46_RS18360	3573478..3574251	+	774	WP_000160654.1	alpha/beta hydrolase	-
ILQ46_RS18365	3574603..3575016	-	414	WP_001151233.1	DUF977 family protein	-
ILQ46_RS18370	3575032..3575802	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ46_RS18375	3575824..3576570	-	747	WP_000788751.1	ATP-binding protein	-
ILQ46_RS18380	3576577..3577668	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T175962 WP_000813263.1 NZ_CP062736:c3572873-3572718 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T175962 NZ_CP082292:3007144-3007359 [Pantoea agglomerans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGTTGCCGCTCTCTGGATACCCTGGAAAGGGTCAT
TGAAAAAAATAAGTATGAATTACCCGAGGATGAATTAGCGGTATTTTACTCCGCAGCCGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCAGGTTCAGTATGGAAATTTGTCCGTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT175962 NZ_CP062736:3572885-3572943 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin