Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3062232..3062703 Replicon chromosome
Accession NZ_CP062736
Organism Escherichia coli O157:H7 strain Z1766

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ILQ46_RS15540 Protein ID WP_001303511.1
Coordinates 3062425..3062703 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ILQ46_RS15535 Protein ID WP_001302048.1
Coordinates 3062232..3062423 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ46_RS15495 3057439..3058023 - 585 WP_000206793.1 DUF551 domain-containing protein -
ILQ46_RS15500 3058080..3058475 - 396 WP_001118159.1 DUF977 family protein -
ILQ46_RS15505 3058491..3059260 - 770 Protein_3032 DUF1627 domain-containing protein -
ILQ46_RS15510 3059286..3060026 - 741 WP_000788938.1 ATP-binding protein -
ILQ46_RS15515 3060033..3060995 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
ILQ46_RS15520 3061018..3061443 - 426 WP_000693943.1 Rha family transcriptional regulator -
ILQ46_RS15525 3061440..3061742 - 303 WP_000172738.1 transcriptional regulator -
ILQ46_RS15530 3061840..3062211 + 372 WP_001169686.1 hypothetical protein -
ILQ46_RS15535 3062232..3062423 + 192 WP_001302048.1 hypothetical protein Antitoxin
ILQ46_RS15540 3062425..3062703 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ46_RS15545 3063056..3063355 + 300 WP_001240334.1 hypothetical protein -
ILQ46_RS15550 3063427..3063645 + 219 WP_001171930.1 hypothetical protein -
ILQ46_RS15555 3064214..3064402 + 189 WP_000449192.1 cell division inhibition protein DicB -
ILQ46_RS15560 3064399..3064590 + 192 WP_001090200.1 DUF1482 family protein -
ILQ46_RS15565 3064683..3067154 + 2472 WP_072612735.1 exonuclease -
ILQ46_RS15570 3067219..3067467 + 249 WP_000113189.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 3021167..3070359 49192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T175960 WP_001303511.1 NZ_CP062736:3062425-3062703 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T175960 NZ_CP082292:2051287-2052600 [Pantoea agglomerans]
ATGCAAAGGCTGATTGCGTGGATGAACGGTGAGCGGGTAGGCGTGCTCACCCGGCAGCGGAATGGCGCTCATGAGTTTCA
GTATGACACCGGCTGGCTGAGTAACCCGCTATCCAGGCCACTGTCACTTTCTCTGCCGCTGCAGGTTAAGGCAATCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCAGATAGCCCGCTGATTCGTGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCGTTTGACCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGTTGCCGCCCGA
TATGCCGCTGCCCGCGCTGCAGGCTCGCTATGAGGTGCTGGATGAAGCCCGGCTTGAGAGTGTGCTGTCAGCCTATCAGT
CAGATATCCCGCTGGGGATGTTGCGTGAAGAGACTGACTTCCGCATTTCGGTGGCGGGCGCACAGGAGAAAACGGCGCTG
CTGCTGACCGAAGAGGGCTGGAGCATTCCTGCCGGTGCCACGCCTACCTCGCACATCATTAAGCTGCCGATCGGTGAGAT
TAAACAGCCAGCCGCGACGCTGGATATGCGTGAAAGCGTAGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGCGCACTGG
GTATTGATGTGCCGCAGGCGACGATTATCCGGGCCGGTAAGATGCGCGCCCTGGCCGTTGAGCGCTTTGATCGCCGCTGG
TCGCGCGACCGAACCCGGCTGATTCGTCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGGCTACCATCCTCGACCAAATA
TGCGTCGGACGGCGGGCCGGGCATTGCAGAAATAATGCAGATACTGATGGGATCGAGCAACGCCATTGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGTGCTACCGATGGTCACGCAAAAAACTTCTCGCTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACACCCTTTTATGATGTGATCTCCGCTTATCCGGTGCTGGGCGGTACCGGCCTGAACAG
GCGTGCACTAAAGCTGGCGATGGGGCTGCGTGCCACTAAGGGGAAGAAGACAGAAATCGACAAAATCTTTCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTCGTCCGTGAGTTTCCC
AAAGCGGTGGTCTCAGTGCGCGAGGCCTTACCGGCCGATTATCCACAGCACATCGCCGACGCCATTTTCAGTCATTCACT
GATTATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT175960 WP_001302048.1 NZ_CP062736:3062232-3062423 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT175960 NZ_CP082292:2051039-2051287 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTTATCCGCCAGCGCAACGGCTGGACCCAGAGTGAACTGGC
GAAAAAGGTTGGCCTGAAACAGGCTACCATCTCTCACTTTGAAAATGCGCCTGACACTACCTCGCTGGCCACGCTGTTTA
AGCTTTTACAGGCGCTGGAAGTGAGTCTGGACGTAGTGGAAAAAGAGGAGGCCAGTGCGCCTCAATTGCATGATGAGGAT
GCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References