Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4474762..4475301 Replicon chromosome
Accession NZ_CP062733
Organism Escherichia coli O157:H7 strain Z1767

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ47_RS22585 Protein ID WP_001303998.1
Coordinates 4475041..4475301 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ47_RS22580 Protein ID WP_000729705.1
Coordinates 4474762..4475022 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ47_RS22560 4470516..4471301 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ47_RS22565 4471273..4472985 + 1713 Protein_4417 flagellar biosynthesis protein FlhA -
ILQ47_RS22570 4473130..4473627 - 498 Protein_4418 REP-associated tyrosine transposase RayT -
ILQ47_RS22575 4473803..4474576 - 774 WP_000543891.1 C40 family peptidase -
ILQ47_RS22580 4474762..4475022 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ47_RS22585 4475041..4475301 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ47_RS22590 4475457..4476197 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ47_RS22595 4476168..4476935 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ47_RS22600 4477040..4477618 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T175932 WP_001303998.1 NZ_CP062733:4475041-4475301 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T175932 NZ_CP082272:c1728721-1728545 [Pasteurella multocida]
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAAACAATCAGCTCTCCCAAGACATCCAAGTAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT175932 WP_000729705.1 NZ_CP062733:4474762-4475022 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT175932 NZ_CP082272:c1728499-1728083 [Pasteurella multocida]
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAACGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCTTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGATTACATCAATGGATTTTTATTTTGAAGATT
TCCGCAAAGTTCCATTACCAAGTGAGGCAAAACAAGATGAAGTTTTAATTGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATTTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAAGAAAT
GCAACGTATTACTAATATCTCGCATAGCACAAAAATTGACACAATAAGCCGTGCTTTATCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References