Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3366925..3367720 Replicon chromosome
Accession NZ_CP062733
Organism Escherichia coli O157:H7 strain Z1767

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ47_RS17300 Protein ID WP_000854914.1
Coordinates 3366925..3367299 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ47_RS17305 Protein ID WP_001280954.1
Coordinates 3367346..3367720 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ47_RS17260 3361929..3362420 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ47_RS17265 3362522..3363076 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ47_RS17270 3363100..3363837 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ47_RS17275 3363892..3364830 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ47_RS17285 3365301..3366143 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ47_RS17290 3366228..3366425 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ47_RS17295 3366437..3366928 - 492 WP_000976853.1 hypothetical protein -
ILQ47_RS17300 3366925..3367299 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ47_RS17305 3367346..3367720 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ47_RS17310 3367883..3368104 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ47_RS17315 3368167..3368643 - 477 WP_001186738.1 RadC family protein -
ILQ47_RS17320 3368659..3369144 - 486 WP_000214398.1 antirestriction protein -
ILQ47_RS17325 3369235..3370053 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ47_RS17330 3370393..3371463 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ47_RS17335 3371460..3372365 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3358311..3369144 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175925 WP_000854914.1 NZ_CP062733:c3367299-3366925 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175925 NZ_CP082269:c4180663-4180292 [Enterobacter sp. C2]
ATGAAGCATCCAGCCCTTTTCGATACGAATATCTTAATCGATCTTTTTAGCGGACATCTTCAGGCAATACAGGTGCTTGA
TGACTACCCTTTTCAACGTGCTATCAGCCTTATCACATGGATGGAGATCATGGTCGGTGCAAAAAAATATCATCAGGAGC
AGCGAACCCGAATCGCCCTGAAGGCGTTTGAGGTTATTGATATTTCACGCGATATAGCTGAAAGCATCGTAATACTAAGA
CAGAAATATAAAATGAAGCTTCCGGACGCGATTATTCTGGCTACAGCGCAGGAGCACCGACGTGAGCTTTTGACGCGTAA
CACCAAAGACTTTGCAGGTATTCCAGGCGTAGTAACACCCTACCAATTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175925 WP_001280954.1 NZ_CP062733:c3367720-3367346 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175925 NZ_CP082269:c4180914-4180666 [Enterobacter sp. C2]
ATGAGTATGGTTACGGGTATGGATATGGGCAGAATATTACTCGACCTGTCGGATGACATGATTAAGCAACTTGACGATCT
CAAGCAGCAGCGCAATCTTCCTCGGGCTGAACTGCTGCGCGAAGCCGTTGAACAATATCTTGAAAAGCAAAATCAAGCCG
AAACCGCTATTGCTAATGCGCTAGGGCTTTGGCAAGGCTGCGATGAAGATGGCCTCGAATATGAAAGGAAACTACGCGGG
GAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References