Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2256630..2257101 | Replicon | chromosome |
| Accession | NZ_CP062733 | ||
| Organism | Escherichia coli O157:H7 strain Z1767 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ47_RS11325 | Protein ID | WP_001303511.1 |
| Coordinates | 2256630..2256908 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ47_RS11330 | Protein ID | WP_001302048.1 |
| Coordinates | 2256910..2257101 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ47_RS11295 | 2251866..2252114 | - | 249 | WP_000113189.1 | excisionase | - |
| ILQ47_RS11300 | 2252179..2254650 | - | 2472 | WP_072612735.1 | exonuclease | - |
| ILQ47_RS11305 | 2254743..2254934 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ47_RS11310 | 2254931..2255119 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ47_RS11315 | 2255688..2255906 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ47_RS11320 | 2255978..2256277 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ47_RS11325 | 2256630..2256908 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ47_RS11330 | 2256910..2257101 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ47_RS11335 | 2257122..2257493 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ47_RS11340 | 2257591..2257893 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ47_RS11345 | 2257890..2258315 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ47_RS11350 | 2258338..2259300 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ47_RS11355 | 2259307..2260047 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ47_RS11360 | 2260073..2260842 | + | 770 | Protein_2219 | DUF1627 domain-containing protein | - |
| ILQ47_RS11365 | 2260858..2261253 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ47_RS11370 | 2261310..2261894 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleA/espI | 2246623..2298164 | 51541 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175913 WP_001303511.1 NZ_CP062733:c2256908-2256630 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175913 NZ_CP082267:c1092541-1092122 [Enterococcus lactis]
GTGATTTCTGAAGGACTTTATTTTGAAGCTGCAGACCTTGCAAATGAACTCTCAGAAGAAGTTAGTTATTACTGTTCAAA
GAAAATGGAACATGTAAAATGCTACGACATTGAGAATTATGTGAATGAAGTAGAAGATGTAGAATTCATCGATTACGACT
TCAAAGATAACTTAAGTAAGAAAATGCTTGGTTCCATTACAAAAGTTCATGGCGAAATCATCATTACTACCAATCAACAT
TTAATGCTTGAACGCAAAAATTTTACAAAAATGCATGAGATCATCCATTATTATAAGGACGTCCCCTATCTTGGAGAATC
TCATGCATTTTCTGATATGATTTTAGAAGATGCTTATTTGCCAGAAGACTATAAAAAAACTTCGAGCAAATATAGGTGCC
AGTATCCTCATGGCGAATGA
GTGATTTCTGAAGGACTTTATTTTGAAGCTGCAGACCTTGCAAATGAACTCTCAGAAGAAGTTAGTTATTACTGTTCAAA
GAAAATGGAACATGTAAAATGCTACGACATTGAGAATTATGTGAATGAAGTAGAAGATGTAGAATTCATCGATTACGACT
TCAAAGATAACTTAAGTAAGAAAATGCTTGGTTCCATTACAAAAGTTCATGGCGAAATCATCATTACTACCAATCAACAT
TTAATGCTTGAACGCAAAAATTTTACAAAAATGCATGAGATCATCCATTATTATAAGGACGTCCCCTATCTTGGAGAATC
TCATGCATTTTCTGATATGATTTTAGAAGATGCTTATTTGCCAGAAGACTATAAAAAAACTTCGAGCAAATATAGGTGCC
AGTATCCTCATGGCGAATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175913 WP_001302048.1 NZ_CP062733:c2257101-2256910 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175913 NZ_CP082267:c1092822-1092565 [Enterococcus lactis]
TTGTTGTCAAATTATCAGCTAGTCACAGTAATAGCAGATTTCTTCAATGTTTCTACAGATTTTCTACTAAATAGAACCTC
TGATCCGACTCCTCCAAAACGTAGCGAAGAAGATCAGCTTGGAGACAGTATTCTTTCTCACTTCAGATTGAATACTGCAG
ATATGGAAGTAGAAGACATTGAAGAATTGGAAGAAGAATTAAATGAATATATGGACTTTTTAGTTCAACGTGCAAAAGCA
AAGAAAAATAAAAAATAG
TTGTTGTCAAATTATCAGCTAGTCACAGTAATAGCAGATTTCTTCAATGTTTCTACAGATTTTCTACTAAATAGAACCTC
TGATCCGACTCCTCCAAAACGTAGCGAAGAAGATCAGCTTGGAGACAGTATTCTTTCTCACTTCAGATTGAATACTGCAG
ATATGGAAGTAGAAGACATTGAAGAATTGGAAGAAGAATTAAATGAATATATGGACTTTTTAGTTCAACGTGCAAAAGCA
AAGAAAAATAAAAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|