Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4474793..4475332 Replicon chromosome
Accession NZ_CP062731
Organism Escherichia coli O157:H7 strain Z1768

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ48_RS22580 Protein ID WP_001303998.1
Coordinates 4475072..4475332 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ48_RS22575 Protein ID WP_000729705.1
Coordinates 4474793..4475053 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ48_RS22555 4470547..4471332 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ48_RS22560 4471304..4473016 + 1713 Protein_4416 flagellar biosynthesis protein FlhA -
ILQ48_RS22565 4473161..4473658 - 498 Protein_4417 REP-associated tyrosine transposase RayT -
ILQ48_RS22570 4473834..4474607 - 774 WP_000543891.1 C40 family peptidase -
ILQ48_RS22575 4474793..4475053 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ48_RS22580 4475072..4475332 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ48_RS22585 4475488..4476228 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ48_RS22590 4476199..4476966 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ48_RS22595 4477071..4477649 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T175894 WP_001303998.1 NZ_CP062731:4475072-4475332 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T175894 NZ_CP082238:501607-502017 [Acidithiobacillus ferrooxidans]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT175894 WP_000729705.1 NZ_CP062731:4474793-4475053 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT175894 NZ_CP082238:501377-501607 [Acidithiobacillus ferrooxidans]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References