175887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3366949..3367744 Replicon chromosome
Accession NZ_CP062731
Organism Escherichia coli O157:H7 strain Z1768

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ48_RS17295 Protein ID WP_000854914.1
Coordinates 3366949..3367323 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ48_RS17300 Protein ID WP_001280954.1
Coordinates 3367370..3367744 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ48_RS17255 3361953..3362444 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ48_RS17260 3362546..3363100 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ48_RS17265 3363124..3363861 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ48_RS17270 3363916..3364854 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ48_RS17280 3365325..3366167 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ48_RS17285 3366252..3366449 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ48_RS17290 3366461..3366952 - 492 WP_000976853.1 hypothetical protein -
ILQ48_RS17295 3366949..3367323 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ48_RS17300 3367370..3367744 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ48_RS17305 3367907..3368128 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ48_RS17310 3368191..3368667 - 477 WP_001186738.1 RadC family protein -
ILQ48_RS17315 3368683..3369168 - 486 WP_000214398.1 antirestriction protein -
ILQ48_RS17320 3369259..3370077 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ48_RS17325 3370417..3371487 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ48_RS17330 3371484..3372389 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3358335..3369168 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175887 WP_000854914.1 NZ_CP062731:c3367323-3366949 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175887 NZ_CP082236:c4587547-4586975 [Pseudomonas sp. SC3(2021)]
ATGGACCTCGAAAAAATCAGCGGACGCCTCGAATTCCTGCGTGAAGCGGAAAAACTCAAGGACGTCCTCAGAAGCGCACA
CACTTCCAGTGGGCGCACCGAAAGTACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATAGTTTTCGCCGATGAAC
TGGCCGGACTCGACCTGCTTAAAGTGCTCAGGATGTGCGTAATTCACGACTTGGGCGAAGCCATCAACGGCGACATTCCG
GCAGTCGATCAGGCCGCGTTCCCCGACAAGAGTGAGCAGGAGCGAAATGACCTCCTGCTGCTGACCCGTTCACTCGATAA
CACCCTGAGAAACGAAATTCTCGCTCTGTGGGACGACTACGAAAATGCCCGGTCAGCCGAAGCCAAAGCGGTCAAGGCGC
TGGACAAGCTCGAGACCCTGCTGCAACACACTCAGGGCCACAACCCGGCCGATTTCGACTACCGCTTCAATCTGACATAC
GGCAAGAAACACACCAGTGCCGCACCGATTTTCGCCGCACTGCGCGCGCTCATCGATCAGGACACCCATGCACGAATCCA
GCAAGCGAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175887 WP_001280954.1 NZ_CP062731:c3367744-3367370 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175887 NZ_CP082236:c4588168-4587623 [Pseudomonas sp. SC3(2021)]
ATGCTCAAACCTGCCCTGCCCGGTATCGCCCTGCGTCGTTGGCGCCTGTTGCATCGCGTCAAGCAAAGCCACGCCGCGCA
GATGTTCAGCGTCACCCAATCGACCATTTCCCGCTGGGAAAGCGGCGTGCTGGCGCTGGATCCGGCTGCGCATCTACAGC
TTGAGCAACTGTTGGCCGCGCGCCTCGACACGGCGGCCGATCAGGCTCTCGCGCGGTTGGTGTGCGAAAGCGCACGACCG
GTTCATCTGGTCTGCGACCTCACCCACCGTTTGCTGGCCTGTTCCCCGGCCCGCGCCGCGCAGTTCTCCAGCCCGCTGAG
CGAATTGCTCGGACAATCGCTGTGGCCTTTCGTGACGCCGGAAATTGCCAACAACGAACGGGCGCTCGACACCCTCGGTT
GGCGCGAACTGCCGGCGCCACCGGCGCTGGAATTTGTCACCGGCAACAATGACTCCGACCTTGTGCCGATCCGCCAGAGC
CTGTGCCGCTGGACGCGTATTCCACTGTCCGACGGCACTGCCGCGCGGCTGGTCGAGACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References