Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3062231..3062702 | Replicon | chromosome |
| Accession | NZ_CP062731 | ||
| Organism | Escherichia coli O157:H7 strain Z1768 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ48_RS15535 | Protein ID | WP_001303511.1 |
| Coordinates | 3062424..3062702 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ48_RS15530 | Protein ID | WP_001302048.1 |
| Coordinates | 3062231..3062422 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ48_RS15490 | 3057438..3058022 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ48_RS15495 | 3058079..3058474 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ48_RS15500 | 3058490..3059259 | - | 770 | Protein_3031 | DUF1627 domain-containing protein | - |
| ILQ48_RS15505 | 3059285..3060025 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ48_RS15510 | 3060032..3060994 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ48_RS15515 | 3061017..3061442 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ48_RS15520 | 3061439..3061741 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ48_RS15525 | 3061839..3062210 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ48_RS15530 | 3062231..3062422 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ48_RS15535 | 3062424..3062702 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ48_RS15540 | 3063055..3063354 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ48_RS15545 | 3063426..3063644 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ48_RS15550 | 3064213..3064401 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ48_RS15555 | 3064398..3064589 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ48_RS15560 | 3064682..3067153 | + | 2472 | WP_072612735.1 | exonuclease | - |
| ILQ48_RS15565 | 3067218..3067466 | + | 249 | WP_000113189.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleA/espI | 3021167..3072709 | 51542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175886 WP_001303511.1 NZ_CP062731:3062424-3062702 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175886 NZ_CP082236:c4131459-4131109 [Pseudomonas sp. SC3(2021)]
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
GCAACTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTTAGCG
ACCAACGAAGAGGGAAAGGTAAACGTAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTACAGCAAAAACGAGCAGGACAATTTGACGCCTGCCCAGAAAAAACTTTTCAGAAAGACACTGGATAAAGA
ACTCAACGCGAGAACCCACTATGAAACGTGA
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
GCAACTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTTAGCG
ACCAACGAAGAGGGAAAGGTAAACGTAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTACAGCAAAAACGAGCAGGACAATTTGACGCCTGCCCAGAAAAAACTTTTCAGAAAGACACTGGATAAAGA
ACTCAACGCGAGAACCCACTATGAAACGTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175886 WP_001302048.1 NZ_CP062731:3062231-3062422 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175886 NZ_CP082236:c4131119-4130805 [Pseudomonas sp. SC3(2021)]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCACAAGGTTCAGTTGCCAAAACTGATGCCGATCACTGCGGATGAAGTCGTCGCCATCCGTCAGCAACTGAATCTGT
CCCGGTCAGTATTCGCAATGTATCTGCGCACCAACACGCGAACGCTGGAAAACTGGGAACAAGGACGAGCGACACCCAAT
GCTCAGGCCACCACCCTGATCCGTCTGGTCGAACGCTTCCCACAAACGATCGAACAACTCGCAGCGCTGACCTGA
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCACAAGGTTCAGTTGCCAAAACTGATGCCGATCACTGCGGATGAAGTCGTCGCCATCCGTCAGCAACTGAATCTGT
CCCGGTCAGTATTCGCAATGTATCTGCGCACCAACACGCGAACGCTGGAAAACTGGGAACAAGGACGAGCGACACCCAAT
GCTCAGGCCACCACCCTGATCCGTCTGGTCGAACGCTTCCCACAAACGATCGAACAACTCGCAGCGCTGACCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|