Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4900135..4900547 Replicon chromosome
Accession NZ_CP062725
Organism Escherichia coli O157:H7 strain Z1813

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag ILQ52_RS24695 Protein ID WP_000132630.1
Coordinates 4900206..4900547 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4900135..4900211 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ52_RS24685 4896762..4898231 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
ILQ52_RS24690 4898231..4899985 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4900135..4900211 - 77 NuclAT_15 - Antitoxin
- 4900135..4900211 - 77 NuclAT_15 - Antitoxin
- 4900135..4900211 - 77 NuclAT_15 - Antitoxin
- 4900135..4900211 - 77 NuclAT_15 - Antitoxin
- 4900135..4900211 - 77 NuclAT_16 - Antitoxin
- 4900135..4900211 - 77 NuclAT_16 - Antitoxin
- 4900135..4900211 - 77 NuclAT_16 - Antitoxin
- 4900135..4900211 - 77 NuclAT_16 - Antitoxin
ILQ52_RS24695 4900206..4900547 + 342 WP_000132630.1 endoribonuclease SymE Toxin
ILQ52_RS24700 4900594..4901757 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
ILQ52_RS24705 4901805..4902686 - 882 WP_001304007.1 DUF262 domain-containing protein -
ILQ52_RS24710 4902783..4902947 - 165 WP_000394274.1 DUF1127 domain-containing protein -
ILQ52_RS24715 4903124..4904536 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
ILQ52_RS24720 4904779..4904979 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4892334..4913561 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T175788 WP_000132630.1 NZ_CP062725:4900206-4900547 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T175788 NZ_CP082203:c1994317-1993988 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATGCTTGCTCCTGCAGTGGAGAAGGAATTGGCAGCTATTTATGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTTGAAGCTTTGGAGAGTTTGCAGATTTTTCCTGAAC
GTGGTTTTAACGCTGATAACCGTTTTGGTAAGCAGGTAGACCCGCCACATCTAACCCGAGGTTACGTTATTGGAAAAGAT
TACATCGTCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGACACCTTTTTGCGACCAAGAGTGATTATGTAAAGTT
ATTGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT175788 NZ_CP062725:c4900211-4900135 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References