Detailed information of TA system TA175786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 4552370..4552909
• Replicon: chromosome
• Accession: NZ_CP062725
• Organism: Escherichia coli O157:H7 strain Z1813

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: ILQ52_RS23120
• Protein ID: WP_001303998.1
• Coordinates: 4552649..4552909 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: C3TP07
• Locus tag: ILQ52_RS23115
• Protein ID: WP_000729705.1
• Coordinates: 4552370..4552630 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ52_RS23095	4548124..4548909	-	786	WP_000207556.1	putative lateral flagellar export/assembly protein LafU	-
ILQ52_RS23100	4548881..4550593	+	1713	Protein_4523	flagellar biosynthesis protein FlhA	-
ILQ52_RS23105	4550738..4551235	-	498	Protein_4524	REP-associated tyrosine transposase RayT	-
ILQ52_RS23110	4551411..4552184	-	774	WP_000543891.1	C40 family peptidase	-
ILQ52_RS23115	4552370..4552630	+	261	WP_000729705.1	type II toxin-antitoxin system antitoxin DinJ	Antitoxin
ILQ52_RS23120	4552649..4552909	+	261	WP_001303998.1	type II toxin-antitoxin system mRNA interferase toxin YafQ	Toxin
ILQ52_RS23125	4553065..4553805	+	741	WP_001225679.1	murein L,D-transpeptidase	-
ILQ52_RS23130	4553776..4554543	-	768	WP_001301698.1	class II glutamine amidotransferase	-
ILQ52_RS23135	4554648..4555226	-	579	WP_000284050.1	D-sedoheptulose 7-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10026.71 Da
• Isoelectric Point: 10.3188

>T175786 WP_001303998.1 NZ_CP062725:4552649-4552909 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Nucleotide

• Length: 261 bp

>T175786 NZ_CP082203:282827-283609 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTACTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCTAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAAGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTCTTAGCTTCGA
AAGGATACCAAGTTTCTTTAGCTGTCATTGGTACTAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATTGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACTGTATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGTATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATACCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGATGGGGCAGGAACGGTTGAGGGAATTGAACAAAGGAAGTAATAAGGGAATGGAGAGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9377.74 Da
• Isoelectric Point: 5.0758

>AT175786 WP_000729705.1 NZ_CP062725:4552370-4552630 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Nucleotide

• Length: 261 bp

>AT175786 NZ_CP082203:282351-282827 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCAGACACACGATTTAACACAACCAGAATTTGCTAAAATGGTCGGTATTTC
ACGCAATAGCCTGAGTCGTTATGAAAATGGGACCAGTACGGTTTCAACAGAGCTTATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGACAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAAAGTAGAA
GTGATTAAAGAACGTGGAGCAGCCATTTTATCGCAGCTCTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGATATGGTACATCATCGGGTGGTGGCTTAA