Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3455509..3456304 Replicon chromosome
Accession NZ_CP062725
Organism Escherichia coli O157:H7 strain Z1813

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ52_RS17920 Protein ID WP_000854914.1
Coordinates 3455509..3455883 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ52_RS17925 Protein ID WP_001280954.1
Coordinates 3455930..3456304 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ52_RS17880 3450513..3451004 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ52_RS17885 3451106..3451660 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ52_RS17890 3451684..3452421 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ52_RS17895 3452476..3453414 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ52_RS17905 3453885..3454727 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ52_RS17910 3454812..3455009 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ52_RS17915 3455021..3455512 - 492 WP_000976853.1 hypothetical protein -
ILQ52_RS17920 3455509..3455883 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ52_RS17925 3455930..3456304 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ52_RS17930 3456467..3456688 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ52_RS17935 3456751..3457227 - 477 WP_001186738.1 RadC family protein -
ILQ52_RS17940 3457243..3457728 - 486 WP_000214398.1 antirestriction protein -
ILQ52_RS17945 3457819..3458637 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ52_RS17950 3458977..3460047 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ52_RS17955 3460044..3460949 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3446895..3457728 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175781 WP_000854914.1 NZ_CP062725:c3455883-3455509 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175781 NZ_CP082201:c1883722-1883393 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175781 WP_001280954.1 NZ_CP062725:c3456304-3455930 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175781 NZ_CP082201:c1883999-1883712 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References