Detailed information of TA system TA175775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2319885..2320256
• Replicon: chromosome
• Accession: NZ_CP062725
• Organism: Escherichia coli O157:H7 strain Z1813

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: ILQ52_RS11715
• Protein ID: WP_042853000.1
• Coordinates: 2320062..2320256 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2319885..2320063 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ52_RS11675	2315327..2315983	-	657	WP_000011656.1	carbon-nitrogen hydrolase family protein	-
ILQ52_RS11680	2316085..2316315	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
ILQ52_RS11685	2316454..2316828	+	375	WP_000168751.1	CopC domain-containing protein YobA	-
ILQ52_RS11690	2316832..2317704	+	873	WP_000879314.1	copper homeostasis membrane protein CopD	-
ILQ52_RS11695	2317717..2318058	+	342	WP_000976483.1	YebY family protein	-
ILQ52_RS11700	2318451..2319527	-	1077	WP_045893699.1	phage integrase Arm DNA-binding domain-containing protein	-
ILQ52_RS11705	2319493..2319774	-	282	WP_001311878.1	excisionase	-
ILQ52_RS11710	2319881..2320069	-	189	WP_001356607.1	DUF1187 family protein	-
-	2319885..2320063	+	179	NuclAT_0	-	Antitoxin
-	2319885..2320063	+	179	NuclAT_0	-	Antitoxin
-	2319885..2320063	+	179	NuclAT_0	-	Antitoxin
-	2319885..2320063	+	179	NuclAT_0	-	Antitoxin
ILQ52_RS11715	2320062..2320256	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
ILQ52_RS11720	2320313..2321122	-	810	WP_000166313.1	recombination protein RecT	-
ILQ52_RS11725	2321115..2323796	-	2682	WP_045893700.1	exodeoxyribonuclease VIII	-
ILQ52_RS11730	2323897..2324173	-	277	Protein_2287	hypothetical protein	-
ILQ52_RS11735	2324248..2324424	-	177	WP_000245528.1	hypothetical protein	-
ILQ52_RS11740	2324418..2324639	-	222	WP_000560227.1	cell division protein FtsZ	-
ILQ52_RS11745	2325048..2325200	-	153	WP_000379547.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2310676..2378298	67622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T175775 WP_042853000.1 NZ_CP062725:c2320256-2320062 [Escherichia coli O157:H7]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T175775 NZ_CP082200:c1882041-1881784 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT175775 NZ_CP062725:2319885-2320063 [Escherichia coli O157:H7]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin