Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3065884..3066355 Replicon chromosome
Accession NZ_CP062723
Organism Escherichia coli O157:H7 strain Z1814

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag ILQ53_RS15560 Protein ID WP_001303511.1
Coordinates 3066077..3066355 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag ILQ53_RS15555 Protein ID WP_001302048.1
Coordinates 3065884..3066075 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ53_RS15515 3061091..3061675 - 585 WP_000206793.1 DUF551 domain-containing protein -
ILQ53_RS15520 3061732..3062127 - 396 WP_001118159.1 DUF977 family protein -
ILQ53_RS15525 3062143..3062912 - 770 Protein_3037 DUF1627 domain-containing protein -
ILQ53_RS15530 3062938..3063678 - 741 WP_000788938.1 ATP-binding protein -
ILQ53_RS15535 3063685..3064647 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
ILQ53_RS15540 3064670..3065095 - 426 WP_000693943.1 Rha family transcriptional regulator -
ILQ53_RS15545 3065092..3065394 - 303 WP_000172738.1 transcriptional regulator -
ILQ53_RS15550 3065492..3065863 + 372 WP_001169686.1 hypothetical protein -
ILQ53_RS15555 3065884..3066075 + 192 WP_001302048.1 hypothetical protein Antitoxin
ILQ53_RS15560 3066077..3066355 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ53_RS15565 3066708..3067007 + 300 WP_001240334.1 hypothetical protein -
ILQ53_RS15570 3067079..3067297 + 219 WP_001171930.1 hypothetical protein -
ILQ53_RS15575 3067866..3068054 + 189 WP_000449192.1 cell division inhibition protein DicB -
ILQ53_RS15580 3068051..3068242 + 192 WP_001090200.1 DUF1482 family protein -
ILQ53_RS15585 3068335..3070806 + 2472 WP_072612735.1 exonuclease -
ILQ53_RS15590 3070871..3071119 + 249 WP_000113189.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 3024821..3074011 49190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T175742 WP_001303511.1 NZ_CP062723:3066077-3066355 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T175742 NZ_CP082164:7128977-7129267 [Bradyrhizobium sp. 186]
ATGATCGAGGTGAGGCAAACCGAGCATTTTTCGGAGTGGCTGAACCGCCTGAAGGACGCCAACGCAGCCGCACGCATCAC
GGTCCGCATTCGCCGCATGGCGATGGGCAATGCCGGCGACAGCAAGAGCGTCGGCCGCAATGTCCGAGAAATGCGCGTCG
ATTATGGGCCGGGCTACCGGATCTACTATGTGCGGCGTGGAGCCCGGATCGTGATCCTGTTGTGTGGCGGCGACAAGCGC
ACACAACAGCAAGACATCGAGCAAGCCCAGAAGCTGGCGGAGACAGTGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT175742 WP_001302048.1 NZ_CP062723:3065884-3066075 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT175742 NZ_CP082164:7129267-7129617 [Bradyrhizobium sp. 186]
ATGCCAAGAGTGGCGAAGACAGCGGCCAAAACGGTATCCAAGACGACGCGATTTGATGCCGCCGACTATCTCAACACCGA
AGAGCGTCAAGCCGCCTATATAGCGGCCGCACTGGAGACCGGCGATGCAGATTTCGTGCGTGACGCGCTCGGTCTCGTCG
CGCGTGCACGCGGCATGAGCGGGATCGCGAAGAAGGCCGGCTTGAACCGCGAAAGTCTGTACAAGGCGCTCGGAGAGACC
GGAAATCCGGAGTTTGGTACGGTGATGCGTATCGTTGGAGCGCTCGGCCTGACACTTTCAGCGCAGCCTGCGGCGAGCGG
GCGGACGTCAAAGCGGCGTCGAGTTGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References